ID   CDX4_MOUSE              Reviewed;         282 AA.
AC   Q07424;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Homeobox protein CDX-4;
DE   AltName: Full=Caudal-type homeobox protein 4;
GN   Name=Cdx4; Synonyms=Cdx-4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7902125; DOI=10.1016/0925-4773(93)90024-r;
RA   Gamer L.W., Wright C.V.;
RT   "Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in
RT   its homeodomain sequence and early expression pattern.";
RL   Mech. Dev. 43:71-81(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Caudal homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L08061; AAA16901.1; -; mRNA.
DR   CCDS; CCDS30328.1; -.
DR   PIR; A56676; A56676.
DR   RefSeq; NP_031700.1; NM_007674.3.
DR   AlphaFoldDB; Q07424; -.
DR   SMR; Q07424; -.
DR   BioGRID; 198665; 3.
DR   IntAct; Q07424; 3.
DR   STRING; 10090.ENSMUSP00000033689; -.
DR   iPTMnet; Q07424; -.
DR   PhosphoSitePlus; Q07424; -.
DR   PaxDb; Q07424; -.
DR   PeptideAtlas; Q07424; -.
DR   PRIDE; Q07424; -.
DR   ProteomicsDB; 280045; -.
DR   Antibodypedia; 13757; 303 antibodies from 34 providers.
DR   DNASU; 12592; -.
DR   Ensembl; ENSMUST00000033689; ENSMUSP00000033689; ENSMUSG00000031326.
DR   GeneID; 12592; -.
DR   KEGG; mmu:12592; -.
DR   UCSC; uc009tzk.1; mouse.
DR   CTD; 1046; -.
DR   MGI; MGI:88362; Cdx4.
DR   VEuPathDB; HostDB:ENSMUSG00000031326; -.
DR   eggNOG; KOG0848; Eukaryota.
DR   GeneTree; ENSGT00940000162554; -.
DR   HOGENOM; CLU_073177_0_0_1; -.
DR   InParanoid; Q07424; -.
DR   OMA; MDPHGPS; -.
DR   OrthoDB; 1380804at2759; -.
DR   PhylomeDB; Q07424; -.
DR   TreeFam; TF351605; -.
DR   BioGRID-ORCS; 12592; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q07424; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q07424; protein.
DR   Bgee; ENSMUSG00000031326; Expressed in embryonic post-anal tail and 23 other tissues.
DR   ExpressionAtlas; Q07424; baseline and differential.
DR   Genevisible; Q07424; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0001568; P:blood vessel development; IGI:MGI.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0060711; P:labyrinthine layer development; IGI:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0001890; P:placenta development; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR006820; Caudal_activation_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF04731; Caudal_act; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Homeobox protein CDX-4"
FT                   /id="PRO_0000048853"
FT   DNA_BIND        171..230
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          13..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   282 AA;  30465 MW;  26E6F295AE451A88 CRC64;
     MYGSCLLEKE AGMYPGTLRS PGGSSTAGVG TSGGSGSPLP ASNFTAAPVY PHYVGYPHMS
     NMDPHGPSLG AWSSPYSPPR EDWSTYPGPP STMGTVPMND MTSPVFGSPD YSTLGPTSGA
     SNGGSLPDAA SESLVSLDSG TSGATSPSRS RHSPYAWMRK TVQVTGKTRT KEKYRVVYTD
     HQRLELEKEF HCNRYITIRR KSELAVNLGL SERQVKIWFQ NRRAKERKMI KKKISQFENT
     GGSVQSDSGS ISPGELPNAF FTTPSAVRGF QPIEIQQVIV SE