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CDY2_HUMAN
ID   CDY2_HUMAN              Reviewed;         541 AA.
AC   Q9Y6F7; A8K868;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Testis-specific chromodomain protein Y 2;
DE            EC=2.3.1.48;
GN   Name=CDY2A; Synonyms=CDY2;
GN   and
GN   Name=CDY2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=10192397; DOI=10.1038/7771;
RA   Lahn B.T., Page D.C.;
RT   "Retroposition of autosomal mRNA yielded testis-specific gene family on
RT   human Y chromosome.";
RL   Nat. Genet. 21:429-433(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.
RX   PubMed=19507244; DOI=10.1002/prot.22472;
RA   Wu H., Min J., Antoshenko T., Plotnikov A.N.;
RT   "Crystal structures of human CDY proteins reveal a crotonase-like fold.";
RL   Proteins 76:1054-1061(2009).
CC   -!- FUNCTION: May have histone acetyltransferase activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC         lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis specific.
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DR   EMBL; AF080598; AAD22733.1; -; mRNA.
DR   EMBL; AK292233; BAF84922.1; -; mRNA.
DR   EMBL; BC069087; AAH69087.1; -; mRNA.
DR   CCDS; CCDS14789.1; -.
DR   CCDS; CCDS35473.1; -.
DR   RefSeq; NP_001001722.1; NM_001001722.1.
DR   RefSeq; NP_004816.1; NM_004825.2.
DR   PDB; 2FW2; X-ray; 2.20 A; A/B/C/D/E/F=282-541.
DR   PDBsum; 2FW2; -.
DR   AlphaFoldDB; Q9Y6F7; -.
DR   SMR; Q9Y6F7; -.
DR   BioGRID; 114819; 20.
DR   BioGRID; 128481; 8.
DR   IntAct; Q9Y6F7; 8.
DR   MINT; Q9Y6F7; -.
DR   iPTMnet; Q9Y6F7; -.
DR   PhosphoSitePlus; Q9Y6F7; -.
DR   BioMuta; CDY2A; -.
DR   DMDM; 20138088; -.
DR   EPD; Q9Y6F7; -.
DR   jPOST; Q9Y6F7; -.
DR   MassIVE; Q9Y6F7; -.
DR   MaxQB; Q9Y6F7; -.
DR   PaxDb; Q9Y6F7; -.
DR   PeptideAtlas; Q9Y6F7; -.
DR   PRIDE; Q9Y6F7; -.
DR   ProteomicsDB; 86669; -.
DR   ABCD; Q9Y6F7; 2 sequenced antibodies.
DR   Antibodypedia; 21874; 67 antibodies from 9 providers.
DR   Antibodypedia; 59758; 37 antibodies from 10 providers.
DR   DNASU; 9426; -.
DR   Ensembl; ENST00000250838.6; ENSP00000250838.4; ENSG00000182415.11.
DR   Ensembl; ENST00000382867.4; ENSP00000372319.3; ENSG00000129873.8.
DR   GeneID; 203611; -.
DR   GeneID; 9426; -.
DR   KEGG; hsa:203611; -.
DR   KEGG; hsa:9426; -.
DR   MANE-Select; ENST00000250838.6; ENSP00000250838.4; NM_004825.2; NP_004816.1.
DR   MANE-Select; ENST00000382867.4; ENSP00000372319.3; NM_001001722.2; NP_001001722.1.
DR   UCSC; uc004ftl.2; human.
DR   CTD; 203611; -.
DR   CTD; 9426; -.
DR   DisGeNET; 203611; -.
DR   DisGeNET; 9426; -.
DR   GeneCards; CDY2A; -.
DR   GeneCards; CDY2B; -.
DR   GeneReviews; CDY2A; -.
DR   HGNC; HGNC:1810; CDY2A.
DR   HGNC; HGNC:23921; CDY2B.
DR   HPA; ENSG00000129873; Not detected.
DR   HPA; ENSG00000182415; Group enriched (epididymis, testis).
DR   MalaCards; CDY2A; -.
DR   MIM; 400018; gene.
DR   neXtProt; NX_Q9Y6F7; -.
DR   OpenTargets; ENSG00000129873; -.
DR   PharmGKB; PA26355; -.
DR   VEuPathDB; HostDB:ENSG00000129873; -.
DR   VEuPathDB; HostDB:ENSG00000182415; -.
DR   GeneTree; ENSGT00940000155106; -.
DR   HOGENOM; CLU_009834_24_0_1; -.
DR   InParanoid; Q9Y6F7; -.
DR   OrthoDB; 1471901at2759; -.
DR   PhylomeDB; Q9Y6F7; -.
DR   TreeFam; TF313375; -.
DR   PathwayCommons; Q9Y6F7; -.
DR   SignaLink; Q9Y6F7; -.
DR   BioGRID-ORCS; 203611; 7 hits in 582 CRISPR screens.
DR   BioGRID-ORCS; 9426; 4 hits in 232 CRISPR screens.
DR   EvolutionaryTrace; Q9Y6F7; -.
DR   Pharos; Q9Y6F7; Tdark.
DR   PRO; PR:Q9Y6F7; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; Q9Y6F7; protein.
DR   Bgee; ENSG00000129873; Expressed in left testis and 1 other tissue.
DR   Genevisible; Q9Y6F7; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR017984; Chromo_dom_subgr.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR023779; Chromodomain_CS.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   PRINTS; PR00504; CHROMODOMAIN.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS00598; CHROMO_1; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acyltransferase; Nucleus; Reference proteome; Transferase.
FT   CHAIN           1..541
FT                   /note="Testis-specific chromodomain protein Y 2"
FT                   /id="PRO_0000080220"
FT   DOMAIN          6..66
FT                   /note="Chromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT   REGION          72..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          286..292
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          295..300
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          303..306
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           312..327
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          331..337
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           348..357
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           359..379
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          384..388
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           395..398
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           400..402
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          403..409
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          413..415
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           418..421
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           429..437
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           439..446
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          451..453
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           454..459
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   STRAND          464..467
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           472..483
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           488..521
FT                   /evidence="ECO:0007829|PDB:2FW2"
FT   HELIX           524..535
FT                   /evidence="ECO:0007829|PDB:2FW2"
SQ   SEQUENCE   541 AA;  60524 MW;  53F31A6603829E85 CRC64;
     MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE
     KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNCK LFAASKNVRR
     KAASTLSDTK NMEIINSTIE TLAPDSPFDH KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE
     GKLLRDPLSH PGAEQTGIQN KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG
     TTDMHTSVPR VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL
     STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY FVRHLRNDRN
     TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL PLCDLVWANE KAWFQTPYTT
     FGQSPDGCSS ITFPKMMGKA SANEMLIAGR KLTAREACAK GLVSQVFLTG TFTQEVMIQI
     KELASYNAIV LEECKALVRC NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE
     F
 
 
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