CDYL2_HUMAN
ID CDYL2_HUMAN Reviewed; 506 AA.
AC Q8N8U2; Q7Z5I8;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Chromodomain Y-like protein 2;
DE Short=CDY-like 2;
GN Name=CDYL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12837688; DOI=10.1093/hmg/ddg185;
RA Dorus S., Gilbert S.L., Forster M.L., Barndt R.J., Lahn B.T.;
RT "The CDY-related gene family: coordinated evolution in copy number,
RT expression profile and protein sequence.";
RL Hum. Mol. Genet. 12:1643-1650(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts (via chromo domain) with histone H3K9me3.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N8U2; Q92997: DVL3; NbExp=3; IntAct=EBI-8467076, EBI-739789;
CC Q8N8U2; O75031: HSF2BP; NbExp=3; IntAct=EBI-8467076, EBI-7116203;
CC Q8N8U2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-8467076, EBI-11742507;
CC Q8N8U2; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-8467076, EBI-398874;
CC Q8N8U2; O14744: PRMT5; NbExp=2; IntAct=EBI-8467076, EBI-351098;
CC Q8N8U2; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-8467076, EBI-12023934;
CC Q8N8U2; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-8467076, EBI-395708;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:12837688}.
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DR EMBL; AY273798; AAP83842.1; -; mRNA.
DR EMBL; AK096185; BAC04720.1; -; mRNA.
DR EMBL; AC092332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069440; AAH69440.1; -; mRNA.
DR EMBL; BC100803; AAI00804.1; -; mRNA.
DR EMBL; BC100804; AAI00805.1; -; mRNA.
DR EMBL; BC100805; AAI00806.1; -; mRNA.
DR EMBL; BC100806; AAI00807.1; -; mRNA.
DR CCDS; CCDS32493.1; -.
DR RefSeq; NP_689555.2; NM_152342.3.
DR PDB; 2MJ8; NMR; -; A=2-64.
DR PDB; 4HAE; X-ray; 2.00 A; A=2-64.
DR PDB; 5JJZ; X-ray; 2.00 A; A=2-66.
DR PDB; 6V2D; X-ray; 2.10 A; A/C/E/G/I/K=2-64.
DR PDB; 6V2H; X-ray; 2.60 A; A/C/E/G/I/K=2-62.
DR PDB; 6V3N; X-ray; 2.70 A; A/B=2-64.
DR PDB; 6V8W; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z=2-62.
DR PDB; 7SLW; X-ray; 2.30 A; A/B/C/D/E/F=2-62.
DR PDBsum; 2MJ8; -.
DR PDBsum; 4HAE; -.
DR PDBsum; 5JJZ; -.
DR PDBsum; 6V2D; -.
DR PDBsum; 6V2H; -.
DR PDBsum; 6V3N; -.
DR PDBsum; 6V8W; -.
DR PDBsum; 7SLW; -.
DR AlphaFoldDB; Q8N8U2; -.
DR BMRB; Q8N8U2; -.
DR SMR; Q8N8U2; -.
DR BioGRID; 125860; 23.
DR IntAct; Q8N8U2; 16.
DR MINT; Q8N8U2; -.
DR STRING; 9606.ENSP00000476295; -.
DR BindingDB; Q8N8U2; -.
DR ChEMBL; CHEMBL3879857; -.
DR iPTMnet; Q8N8U2; -.
DR PhosphoSitePlus; Q8N8U2; -.
DR BioMuta; CDYL2; -.
DR DMDM; 229462825; -.
DR EPD; Q8N8U2; -.
DR jPOST; Q8N8U2; -.
DR MassIVE; Q8N8U2; -.
DR MaxQB; Q8N8U2; -.
DR PaxDb; Q8N8U2; -.
DR PeptideAtlas; Q8N8U2; -.
DR PRIDE; Q8N8U2; -.
DR ProteomicsDB; 72459; -.
DR ABCD; Q8N8U2; 1 sequenced antibody.
DR Antibodypedia; 30424; 97 antibodies from 22 providers.
DR DNASU; 124359; -.
DR Ensembl; ENST00000570137.7; ENSP00000476295.1; ENSG00000166446.15.
DR GeneID; 124359; -.
DR KEGG; hsa:124359; -.
DR MANE-Select; ENST00000570137.7; ENSP00000476295.1; NM_152342.4; NP_689555.2.
DR UCSC; uc002ffs.4; human.
DR CTD; 124359; -.
DR DisGeNET; 124359; -.
DR GeneCards; CDYL2; -.
DR HGNC; HGNC:23030; CDYL2.
DR HPA; ENSG00000166446; Tissue enhanced (brain).
DR MIM; 618816; gene.
DR neXtProt; NX_Q8N8U2; -.
DR OpenTargets; ENSG00000166446; -.
DR PharmGKB; PA134903387; -.
DR VEuPathDB; HostDB:ENSG00000166446; -.
DR eggNOG; KOG0016; Eukaryota.
DR eggNOG; KOG1911; Eukaryota.
DR GeneTree; ENSGT00940000159646; -.
DR HOGENOM; CLU_009834_24_0_1; -.
DR InParanoid; Q8N8U2; -.
DR OMA; EQDLGEC; -.
DR OrthoDB; 1471901at2759; -.
DR PhylomeDB; Q8N8U2; -.
DR TreeFam; TF313375; -.
DR PathwayCommons; Q8N8U2; -.
DR SignaLink; Q8N8U2; -.
DR BioGRID-ORCS; 124359; 10 hits in 1076 CRISPR screens.
DR ChiTaRS; CDYL2; human.
DR GenomeRNAi; 124359; -.
DR Pharos; Q8N8U2; Tchem.
DR PRO; PR:Q8N8U2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N8U2; protein.
DR Bgee; ENSG00000166446; Expressed in cerebellar vermis and 171 other tissues.
DR ExpressionAtlas; Q8N8U2; baseline and differential.
DR Genevisible; Q8N8U2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR Gene3D; 1.10.12.10; -; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome.
FT CHAIN 1..506
FT /note="Chromodomain Y-like protein 2"
FT /id="PRO_0000080223"
FT DOMAIN 7..67
FT /note="Chromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT REGION 64..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 196
FT /note="N -> D (in Ref. 2; BAC04720)"
FT /evidence="ECO:0000305"
FT STRAND 6..17
FT /evidence="ECO:0007829|PDB:4HAE"
FT STRAND 23..29
FT /evidence="ECO:0007829|PDB:4HAE"
FT TURN 30..32
FT /evidence="ECO:0007829|PDB:2MJ8"
FT HELIX 34..36
FT /evidence="ECO:0007829|PDB:4HAE"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:4HAE"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:4HAE"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:4HAE"
FT HELIX 49..56
FT /evidence="ECO:0007829|PDB:6V2D"
SQ SEQUENCE 506 AA; 56500 MW; C5093B57FDF6AEBE CRC64;
MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE FIDEFNGLHM
SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK GTSHKRKRIN PPLAKPKKGY
SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK KSQNGMENGD AGSEKDERHF GNGSHQPGLD
LNDHVGEQDM GECDVNHATL AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV
RQNESNCRFR DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL
SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV VAINGPALGL
GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ ILGVALANEM LFCGRKLTAQ
EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS CSAVVLEESK CLVRSFLKSV LEDVNEKECL
MLKQLWSSSK GLDSLFSYLQ DKIYEV
