CDYL2_MOUSE
ID CDYL2_MOUSE Reviewed; 503 AA.
AC Q9D5D8;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Chromodomain Y-like protein 2;
DE Short=CDY-like 2;
GN Name=Cdyl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH HISTONE H3K9ME3, AND SUBCELLULAR LOCATION.
RX PubMed=18450745; DOI=10.1074/jbc.m802655200;
RA Fischle W., Franz H., Jacobs S.A., Allis C.D., Khorasanizadeh S.;
RT "Specificity of the chromodomain Y chromosome family of chromodomains for
RT lysine-methylated ARK(S/T) motifs.";
RL J. Biol. Chem. 283:19626-19635(2008).
CC -!- SUBUNIT: Interacts (via chromo domain) with histone H3K9me3.
CC {ECO:0000269|PubMed:18450745}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18450745}.
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DR EMBL; AK015452; BAB29852.1; -; mRNA.
DR EMBL; AC108439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466525; EDL11564.1; -; Genomic_DNA.
DR EMBL; BC058956; AAH58956.1; -; mRNA.
DR CCDS; CCDS40488.1; -.
DR RefSeq; NP_083717.1; NM_029441.3.
DR AlphaFoldDB; Q9D5D8; -.
DR BMRB; Q9D5D8; -.
DR SMR; Q9D5D8; -.
DR BioGRID; 217748; 1.
DR STRING; 10090.ENSMUSP00000104730; -.
DR iPTMnet; Q9D5D8; -.
DR PhosphoSitePlus; Q9D5D8; -.
DR EPD; Q9D5D8; -.
DR jPOST; Q9D5D8; -.
DR MaxQB; Q9D5D8; -.
DR PaxDb; Q9D5D8; -.
DR PRIDE; Q9D5D8; -.
DR ProteomicsDB; 281359; -.
DR Antibodypedia; 30424; 97 antibodies from 22 providers.
DR Ensembl; ENSMUST00000109102; ENSMUSP00000104730; ENSMUSG00000031758.
DR GeneID; 75796; -.
DR KEGG; mmu:75796; -.
DR UCSC; uc009noi.2; mouse.
DR CTD; 124359; -.
DR MGI; MGI:1923046; Cdyl2.
DR VEuPathDB; HostDB:ENSMUSG00000031758; -.
DR eggNOG; KOG0016; Eukaryota.
DR eggNOG; KOG1911; Eukaryota.
DR GeneTree; ENSGT00940000159646; -.
DR HOGENOM; CLU_009834_24_0_1; -.
DR InParanoid; Q9D5D8; -.
DR OMA; EQDLGEC; -.
DR OrthoDB; 1471901at2759; -.
DR PhylomeDB; Q9D5D8; -.
DR TreeFam; TF313375; -.
DR BioGRID-ORCS; 75796; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Cdyl2; mouse.
DR PRO; PR:Q9D5D8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D5D8; protein.
DR Bgee; ENSMUSG00000031758; Expressed in blastocyst and 88 other tissues.
DR Genevisible; Q9D5D8; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0035064; F:methylated histone binding; IDA:MGI.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR Gene3D; 1.10.12.10; -; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..503
FT /note="Chromodomain Y-like protein 2"
FT /id="PRO_0000424594"
FT DOMAIN 7..67
FT /note="Chromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT REGION 66..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 56142 MW; AE9F2426CA963B26 CRC64;
MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE FIDEFNGLHL
SKDKRVKSGK QAGASKLLRD ARGLPVERLS HRPLEPGKSK PSSHKRKRVN SPLSRPKKGS
SGKAPDRATK TVSYRTTPSG LQIMPLKKAQ NGLENGDAGS EKDESHFGNG SHQPDLELND
QLGEQEASDC DGTHSALVEN GVGSALTNGG LNLHSPVKRK LETEKDYVFD KRLRYSVRQN
ESNCRFRDIV VRKEEGFTHI LLSSQTSDNN ALTPEIMKEV RRALCNAATD DSKLLLLSAV
GSVFCSGLDY SYLIGRLSSD RRKESTRIAE AIRDFVKAFI QFKKPIVVAI NGPALGLGAS
ILPLCDIVWA SEKAWFQTPY ATIRLTPAGC SSYTFPQILG VALANEMLFC GRKLTAQEAC
SRGLVSQVFW PTTFSQEVML RVKEMASCSA VVLEESKCLV RSFLKSVLEE VNEKECVMLK
QLWSSSKGLD SLFSYLQDKI YEV
