CE022_HUMAN
ID CE022_HUMAN Reviewed; 442 AA.
AC Q49AR2; Q8ND28; Q8WU61; Q9NUR1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=UPF0489 protein C5orf22;
GN Name=C5orf22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- INTERACTION:
CC Q49AR2; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-746224, EBI-742054;
CC Q49AR2; P60002: ELOF1; NbExp=6; IntAct=EBI-746224, EBI-714648;
CC Q49AR2; Q9Y2W2: WBP11; NbExp=5; IntAct=EBI-746224, EBI-714455;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q49AR2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q49AR2-2; Sequence=VSP_028183;
CC Name=3;
CC IsoId=Q49AR2-3; Sequence=VSP_028182, VSP_028184;
CC -!- SIMILARITY: Belongs to the UPF0489 family. {ECO:0000305}.
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DR EMBL; AK002055; BAA92060.1; -; mRNA.
DR EMBL; AL834427; CAD39088.2; -; mRNA.
DR EMBL; CH471118; EAX10771.1; -; Genomic_DNA.
DR EMBL; CH471118; EAX10772.1; -; Genomic_DNA.
DR EMBL; BC021215; AAH21215.1; -; mRNA.
DR EMBL; BC032845; AAH32845.1; -; mRNA.
DR CCDS; CCDS3895.1; -. [Q49AR2-1]
DR RefSeq; NP_060826.2; NM_018356.2. [Q49AR2-1]
DR RefSeq; XP_006714543.1; XM_006714480.3. [Q49AR2-2]
DR RefSeq; XP_016865102.1; XM_017009613.1. [Q49AR2-2]
DR RefSeq; XP_016865103.1; XM_017009614.1. [Q49AR2-2]
DR RefSeq; XP_016865104.1; XM_017009615.1. [Q49AR2-2]
DR RefSeq; XP_016865105.1; XM_017009616.1. [Q49AR2-2]
DR AlphaFoldDB; Q49AR2; -.
DR BioGRID; 120603; 23.
DR IntAct; Q49AR2; 6.
DR STRING; 9606.ENSP00000326879; -.
DR GlyGen; Q49AR2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q49AR2; -.
DR PhosphoSitePlus; Q49AR2; -.
DR BioMuta; C5orf22; -.
DR EPD; Q49AR2; -.
DR jPOST; Q49AR2; -.
DR MassIVE; Q49AR2; -.
DR MaxQB; Q49AR2; -.
DR PaxDb; Q49AR2; -.
DR PeptideAtlas; Q49AR2; -.
DR PRIDE; Q49AR2; -.
DR ProteomicsDB; 62065; -. [Q49AR2-1]
DR ProteomicsDB; 62066; -. [Q49AR2-2]
DR ProteomicsDB; 62067; -. [Q49AR2-3]
DR Antibodypedia; 51883; 69 antibodies from 14 providers.
DR DNASU; 55322; -.
DR Ensembl; ENST00000325366.14; ENSP00000326879.9; ENSG00000082213.18. [Q49AR2-1]
DR GeneID; 55322; -.
DR KEGG; hsa:55322; -.
DR MANE-Select; ENST00000325366.14; ENSP00000326879.9; NM_018356.3; NP_060826.2.
DR UCSC; uc003jhj.4; human. [Q49AR2-1]
DR CTD; 55322; -.
DR DisGeNET; 55322; -.
DR GeneCards; C5orf22; -.
DR HGNC; HGNC:25639; C5orf22.
DR HPA; ENSG00000082213; Low tissue specificity.
DR neXtProt; NX_Q49AR2; -.
DR OpenTargets; ENSG00000082213; -.
DR PharmGKB; PA144596503; -.
DR VEuPathDB; HostDB:ENSG00000082213; -.
DR eggNOG; ENOG502QW2U; Eukaryota.
DR GeneTree; ENSGT00390000001801; -.
DR HOGENOM; CLU_046339_0_0_1; -.
DR InParanoid; Q49AR2; -.
DR OMA; DQTCLEP; -.
DR OrthoDB; 1501156at2759; -.
DR PhylomeDB; Q49AR2; -.
DR TreeFam; TF324160; -.
DR PathwayCommons; Q49AR2; -.
DR SignaLink; Q49AR2; -.
DR BioGRID-ORCS; 55322; 17 hits in 1055 CRISPR screens.
DR ChiTaRS; C5orf22; human.
DR GenomeRNAi; 55322; -.
DR Pharos; Q49AR2; Tdark.
DR PRO; PR:Q49AR2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q49AR2; protein.
DR Bgee; ENSG00000082213; Expressed in secondary oocyte and 206 other tissues.
DR ExpressionAtlas; Q49AR2; baseline and differential.
DR Genevisible; Q49AR2; HS.
DR InterPro; IPR024131; UPF0489.
DR PANTHER; PTHR13225; PTHR13225; 1.
DR Pfam; PF12640; UPF0489; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..442
FT /note="UPF0489 protein C5orf22"
FT /id="PRO_0000305002"
FT REGION 175..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..279
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028182"
FT VAR_SEQ 1..265
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028183"
FT VAR_SEQ 280..353
FT /note="QFKKPGTNLTEEDLVDIVDTRIHQLEDLEATFADLCDGDDEETVQRWASNPG
FT MESLVPLVQSLKKRMEVPDYEM -> MEVPDYEMFPASSSSPSETTSAWISLSMSLSAF
FT WSKPFNKSLGSSKLSNISLPSSEPSKLFQPLPVPKLLPHFQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028184"
FT VARIANT 235
FT /note="T -> P (in dbSNP:rs17410000)"
FT /id="VAR_035149"
FT VARIANT 405
FT /note="D -> E (in dbSNP:rs16901277)"
FT /id="VAR_035150"
FT CONFLICT 199
FT /note="S -> P (in Ref. 1; BAA92060)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 442 AA; 49967 MW; A79A014E358C7367 CRC64;
MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH FDSHPDLLIP
VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH PTWAQQIREG RHHFLVGKDT
STTTIRVTST DHYFLSDGLY VPEDQLENQK PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP
KLALEDSENT ASTNCDSSSE GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE
ILKKGKAFVL DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR
IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD YEMVHQAGLT
CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR SSLDDYCPSD QVDTIQEKVL
NMLRALYGNL DLQVYAAESP PS
