CE022_MOUSE
ID CE022_MOUSE Reviewed; 442 AA.
AC Q8BGC1; B2RQ49; Q8BYV3; Q8BZ46; Q9CX64;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=UPF0489 protein C5orf22 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Bone, Cerebellum, Head, Hypothalamus, Oviduct, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-285, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BGC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGC1-2; Sequence=VSP_028185;
CC Name=3;
CC IsoId=Q8BGC1-3; Sequence=VSP_028186;
CC -!- SIMILARITY: Belongs to the UPF0489 family. {ECO:0000305}.
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DR EMBL; AK020074; BAB31984.1; -; mRNA.
DR EMBL; AK035859; BAC29215.1; -; mRNA.
DR EMBL; AK036721; BAC29550.2; -; mRNA.
DR EMBL; AK037867; BAC29887.1; -; mRNA.
DR EMBL; AK038561; BAC30044.1; -; mRNA.
DR EMBL; AK054133; BAC35665.1; -; mRNA.
DR EMBL; AK081625; BAC38275.1; -; mRNA.
DR EMBL; BC119058; AAI19059.1; -; mRNA.
DR EMBL; BC028769; AAH28769.1; -; mRNA.
DR EMBL; BC099607; AAH99607.1; -; mRNA.
DR EMBL; BC137759; AAI37760.1; -; mRNA.
DR CCDS; CCDS27392.1; -. [Q8BGC1-1]
DR RefSeq; NP_001159832.1; NM_001166360.1. [Q8BGC1-3]
DR RefSeq; NP_084274.1; NM_029998.3. [Q8BGC1-1]
DR AlphaFoldDB; Q8BGC1; -.
DR STRING; 10090.ENSMUSP00000055656; -.
DR iPTMnet; Q8BGC1; -.
DR PhosphoSitePlus; Q8BGC1; -.
DR EPD; Q8BGC1; -.
DR MaxQB; Q8BGC1; -.
DR PaxDb; Q8BGC1; -.
DR PeptideAtlas; Q8BGC1; -.
DR PRIDE; Q8BGC1; -.
DR Antibodypedia; 51883; 69 antibodies from 14 providers.
DR DNASU; 77877; -.
DR Ensembl; ENSMUST00000057256; ENSMUSP00000055656; ENSMUSG00000022195. [Q8BGC1-1]
DR Ensembl; ENSMUST00000228177; ENSMUSP00000154147; ENSMUSG00000022195. [Q8BGC1-2]
DR GeneID; 77877; -.
DR KEGG; mmu:77877; -.
DR UCSC; uc007vhw.2; mouse. [Q8BGC1-1]
DR UCSC; uc007vhx.2; mouse. [Q8BGC1-2]
DR UCSC; uc007vhz.2; mouse. [Q8BGC1-3]
DR MGI; MGI:1925127; 6030458C11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000022195; -.
DR eggNOG; ENOG502QW2U; Eukaryota.
DR GeneTree; ENSGT00390000001801; -.
DR HOGENOM; CLU_046339_0_0_1; -.
DR InParanoid; Q8BGC1; -.
DR OMA; DQTCLEP; -.
DR OrthoDB; 1501156at2759; -.
DR PhylomeDB; Q8BGC1; -.
DR TreeFam; TF324160; -.
DR BioGRID-ORCS; 77877; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q8BGC1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BGC1; protein.
DR Bgee; ENSMUSG00000022195; Expressed in animal zygote and 235 other tissues.
DR ExpressionAtlas; Q8BGC1; baseline and differential.
DR Genevisible; Q8BGC1; MM.
DR InterPro; IPR024131; UPF0489.
DR PANTHER; PTHR13225; PTHR13225; 1.
DR Pfam; PF12640; UPF0489; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..442
FT /note="UPF0489 protein C5orf22 homolog"
FT /id="PRO_0000305003"
FT REGION 167..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 15
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 28..178
FT /note="VLPFIYRAIGSKHLPDSNISFLHLDSHPDLLIPVNMPADTVFDKEALFGELS
FT IENWIMPAVYAGHFSQVIWLHPTWAQQIREGKHCFLVGKDISTTTIRVTSTDSYFLSDG
FT LFVPEDQLENRRPLQLDVILVEPYTLCSKQDDSDSVSSTK -> RTEYRKLDYACSLRW
FT PFFSSNLAPPHVGPANQGGQALLLSRQRHFYHNHQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028185"
FT VAR_SEQ 127..442
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_028186"
FT CONFLICT 12
FT /note="R -> K (in Ref. 1; BAC29550)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 442 AA; 49430 MW; ABB258105F715951 CRC64;
MSDTGGDRAR LRRYTKLPVW VVEDHQEVLP FIYRAIGSKH LPDSNISFLH LDSHPDLLIP
VNMPADTVFD KEALFGELSI ENWIMPAVYA GHFSQVIWLH PTWAQQIREG KHCFLVGKDI
STTTIRVTST DSYFLSDGLF VPEDQLENRR PLQLDVILVE PYTLCSKQDD SDSVSSTKKP
KLALGSGESS AAADGHSCSE GRRGDAVTPR SDHACQEPSC SRSGGQQSQN TATAGAILDI
LKTGDAFVLD IDLDFFSVKN PFKEMFTQDE YKILQELYQF KKPDSNLPED GLVDVVEART
HQLEDLEAVF ADLCDGDSEE TVQSWASNPG MESLVPLVQS LKKRMEVPDY EMVHQAGLTC
DYSELPHHIS TEEEIEYLIQ SVYFLLKSLP KPTLVTIARS SLDDYCPPEQ VDMIQGKVLD
VLHSLYGTLD THLVYSEESP LS
