CE024_HUMAN
ID CE024_HUMAN Reviewed; 188 AA.
AC Q7Z6I8; D3DQA7; Q86Y53; Q8N1T9;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=UPF0461 protein C5orf24;
GN Name=C5orf24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Blood;
RA Konstantinopoulou V.;
RT "Physical and hematopoietic transcript map of a 5q31 critical subregion
RT associated with the 5q- syndrome.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121 AND SER-180, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-75, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-75, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25755297; DOI=10.1074/mcp.o114.044792;
RA Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V.,
RA Vertegaal A.C.;
RT "System-wide analysis of SUMOylation dynamics in response to replication
RT stress reveals novel small ubiquitin-like modified target proteins and
RT acceptor lysines relevant for genome stability.";
RL Mol. Cell. Proteomics 14:1419-1434(2015).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-75 AND LYS-184, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q7Z6I8; O95967: EFEMP2; NbExp=3; IntAct=EBI-9995695, EBI-743414;
CC Q7Z6I8; O75928-2: PIAS2; NbExp=3; IntAct=EBI-9995695, EBI-348567;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z6I8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z6I8-2; Sequence=VSP_027011;
CC -!- SIMILARITY: Belongs to the UPF0461 family. {ECO:0000305}.
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DR EMBL; AJ437658; CAD26900.2; -; mRNA.
DR EMBL; AK094881; BAC04448.1; -; mRNA.
DR EMBL; CH471062; EAW62234.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62235.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62236.1; -; Genomic_DNA.
DR EMBL; BC053677; AAH53677.1; -; mRNA.
DR CCDS; CCDS4179.1; -. [Q7Z6I8-1]
DR CCDS; CCDS75307.1; -. [Q7Z6I8-2]
DR RefSeq; NP_001129058.1; NM_001135586.1. [Q7Z6I8-1]
DR RefSeq; NP_001287823.1; NM_001300894.1. [Q7Z6I8-2]
DR RefSeq; NP_689622.2; NM_152409.3. [Q7Z6I8-1]
DR RefSeq; XP_005271946.1; XM_005271889.3. [Q7Z6I8-1]
DR RefSeq; XP_016864538.1; XM_017009049.1. [Q7Z6I8-1]
DR RefSeq; XP_016864539.1; XM_017009050.1. [Q7Z6I8-1]
DR AlphaFoldDB; Q7Z6I8; -.
DR BioGRID; 126409; 43.
DR IntAct; Q7Z6I8; 28.
DR MINT; Q7Z6I8; -.
DR STRING; 9606.ENSP00000378427; -.
DR GlyGen; Q7Z6I8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z6I8; -.
DR PhosphoSitePlus; Q7Z6I8; -.
DR BioMuta; C5orf24; -.
DR DMDM; 74738816; -.
DR EPD; Q7Z6I8; -.
DR jPOST; Q7Z6I8; -.
DR MassIVE; Q7Z6I8; -.
DR MaxQB; Q7Z6I8; -.
DR PaxDb; Q7Z6I8; -.
DR PeptideAtlas; Q7Z6I8; -.
DR PRIDE; Q7Z6I8; -.
DR ProteomicsDB; 69415; -. [Q7Z6I8-1]
DR ProteomicsDB; 69416; -. [Q7Z6I8-2]
DR Antibodypedia; 45237; 76 antibodies from 15 providers.
DR DNASU; 134553; -.
DR Ensembl; ENST00000338051.4; ENSP00000337044.4; ENSG00000181904.9. [Q7Z6I8-1]
DR Ensembl; ENST00000394976.4; ENSP00000378427.3; ENSG00000181904.9. [Q7Z6I8-1]
DR Ensembl; ENST00000435259.2; ENSP00000395764.2; ENSG00000181904.9. [Q7Z6I8-1]
DR Ensembl; ENST00000504727.1; ENSP00000421647.1; ENSG00000181904.9. [Q7Z6I8-2]
DR GeneID; 134553; -.
DR KEGG; hsa:134553; -.
DR MANE-Select; ENST00000394976.4; ENSP00000378427.3; NM_001135586.1; NP_001129058.1.
DR UCSC; uc003kzx.4; human. [Q7Z6I8-1]
DR CTD; 134553; -.
DR GeneCards; C5orf24; -.
DR HGNC; HGNC:26746; C5orf24.
DR HPA; ENSG00000181904; Low tissue specificity.
DR neXtProt; NX_Q7Z6I8; -.
DR OpenTargets; ENSG00000181904; -.
DR PharmGKB; PA144596505; -.
DR VEuPathDB; HostDB:ENSG00000181904; -.
DR eggNOG; ENOG502RZTV; Eukaryota.
DR GeneTree; ENSGT00390000014889; -.
DR HOGENOM; CLU_090677_0_0_1; -.
DR InParanoid; Q7Z6I8; -.
DR OMA; AAHFDLC; -.
DR OrthoDB; 1331530at2759; -.
DR PhylomeDB; Q7Z6I8; -.
DR TreeFam; TF333072; -.
DR PathwayCommons; Q7Z6I8; -.
DR SignaLink; Q7Z6I8; -.
DR BioGRID-ORCS; 134553; 7 hits in 1049 CRISPR screens.
DR ChiTaRS; C5orf24; human.
DR GenomeRNAi; 134553; -.
DR Pharos; Q7Z6I8; Tdark.
DR PRO; PR:Q7Z6I8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q7Z6I8; protein.
DR Bgee; ENSG00000181904; Expressed in kidney epithelium and 194 other tissues.
DR ExpressionAtlas; Q7Z6I8; baseline and differential.
DR Genevisible; Q7Z6I8; HS.
DR InterPro; IPR040419; DUF5568.
DR PANTHER; PTHR31894; PTHR31894; 1.
DR Pfam; PF17724; DUF5568; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..188
FT /note="UPF0461 protein C5orf24"
FT /id="PRO_0000295708"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 75
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447,
FT ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733"
FT CROSSLNK 184
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 144..188
FT /note="SIKALSRLADLGYGCGTAAFPYPMMHGRAVHGVEETSSEVKPPNE -> KKQ
FT QAFRCSSDA (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_027011"
FT CONFLICT 161
FT /note="A -> V (in Ref. 2; BAC04448)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 188 AA; 20132 MW; BB335B61BD2B7DC8 CRC64;
MMHPVASSNP AFCGPGKPSC LNEDAMRAAD QFDIYSSQQS KYSHTVNHKP MVCQRQDPLN
ETHLQTTSGR SIEIKDELKK KKNLNRSGKR GRPSGTTKSA GYRTSTGRPL GTTKAAGFKT
SPGRPLGTTK AAGYKVSPGR PPGSIKALSR LADLGYGCGT AAFPYPMMHG RAVHGVEETS
SEVKPPNE
