ID   CE034_HUMAN             Reviewed;         638 AA.
AC   Q96MH7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Uncharacterized protein C5orf34;
GN   Name=C5orf34;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pulmonary artery;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   VARIANT [LARGE SCALE ANALYSIS] ARG-266.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
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DR   EMBL; AK056925; BAB71311.1; -; mRNA.
DR   EMBL; AC025457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036867; AAH36867.1; -; mRNA.
DR   CCDS; CCDS3946.1; -.
DR   RefSeq; NP_940968.1; NM_198566.3.
DR   AlphaFoldDB; Q96MH7; -.
DR   BioGRID; 131979; 28.
DR   IntAct; Q96MH7; 14.
DR   STRING; 9606.ENSP00000303490; -.
DR   iPTMnet; Q96MH7; -.
DR   PhosphoSitePlus; Q96MH7; -.
DR   BioMuta; C5orf34; -.
DR   DMDM; 338817858; -.
DR   EPD; Q96MH7; -.
DR   jPOST; Q96MH7; -.
DR   MassIVE; Q96MH7; -.
DR   MaxQB; Q96MH7; -.
DR   PaxDb; Q96MH7; -.
DR   PeptideAtlas; Q96MH7; -.
DR   PRIDE; Q96MH7; -.
DR   ProteomicsDB; 77360; -.
DR   Antibodypedia; 50296; 23 antibodies from 7 providers.
DR   DNASU; 375444; -.
DR   Ensembl; ENST00000306862.7; ENSP00000303490.2; ENSG00000172244.9.
DR   GeneID; 375444; -.
DR   KEGG; hsa:375444; -.
DR   MANE-Select; ENST00000306862.7; ENSP00000303490.2; NM_198566.4; NP_940968.1.
DR   UCSC; uc003jnz.3; human.
DR   CTD; 375444; -.
DR   DisGeNET; 375444; -.
DR   GeneCards; C5orf34; -.
DR   HGNC; HGNC:24738; C5orf34.
DR   HPA; ENSG00000172244; Low tissue specificity.
DR   neXtProt; NX_Q96MH7; -.
DR   OpenTargets; ENSG00000172244; -.
DR   PharmGKB; PA162380068; -.
DR   VEuPathDB; HostDB:ENSG00000172244; -.
DR   eggNOG; ENOG502QSYT; Eukaryota.
DR   GeneTree; ENSGT00500000044987; -.
DR   HOGENOM; CLU_029198_0_0_1; -.
DR   InParanoid; Q96MH7; -.
DR   OrthoDB; 833549at2759; -.
DR   PhylomeDB; Q96MH7; -.
DR   TreeFam; TF328443; -.
DR   PathwayCommons; Q96MH7; -.
DR   SignaLink; Q96MH7; -.
DR   BioGRID-ORCS; 375444; 13 hits in 1050 CRISPR screens.
DR   ChiTaRS; C5orf34; human.
DR   GenomeRNAi; 375444; -.
DR   Pharos; Q96MH7; Tdark.
DR   PRO; PR:Q96MH7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q96MH7; protein.
DR   Bgee; ENSG00000172244; Expressed in secondary oocyte and 123 other tissues.
DR   ExpressionAtlas; Q96MH7; baseline and differential.
DR   Genevisible; Q96MH7; HS.
DR   InterPro; IPR027865; DUF4520.
DR   InterPro; IPR027830; DUF4524.
DR   Pfam; PF15016; DUF4520; 1.
DR   Pfam; PF15025; DUF4524; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..638
FT                   /note="Uncharacterized protein C5orf34"
FT                   /id="PRO_0000295897"
FT   VARIANT         266
FT                   /note="S -> R (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035618"
SQ   SEQUENCE   638 AA;  72884 MW;  65ABB9EEDB786362 CRC64;
     MAAELRMILY EDDSVQVQYV DGSTLQLSPC GSEFLFEKSP PVSAHPLEQP ERIRQRTHFV
     ISTYREQLQR ALDFRNSSAT CPFLSETIIP SERKKHIFID ITEVRWPSLD TDGTMIYMES
     GIVKITSLDG HAYLCLPRSQ HEFTVHFLCK VSQKSDSSAV LSETNNKAPK DKLVEKTGKI
     CIRGNLPGQR LKNKENEFHC QIMKSKETLK KMSCVNGTEG REELPSPGTK HTCVYTWVKQ
     CWSVAACPEE WKYPLSLALH FHNKISNMSK IDAHITQSRF LTSDISEERG KVVSVLPRAL
     SLSCPVPHLH RWNFCDSLLQ RQSDEYSYPE LVKMVWYKGV TYRLTHQNMN SIEIYSGDGS
     VFKSEGAYFG NYFTYYSIQE GSGKREEKTY SVNNLPPDRP GSPFTVGSLI KQATRILQHC
     VKMRLSLSHN YRICCWKMVP GINDSNILPL VLKESLIPSV GRFLAYSDDK VHAIFLDGIT
     LTLNWNFSSP IEKRQVNQGL NLGWCKLTFP DGQEQLIQIE HPEPYERYVT TVTSWCRRLT
     QTSPREMPTH SSSSVLQENW SVASELEKIQ KFNLLLENSG ILNQISNKKN EQQSFDHYKP
     GSSETLLGEV NENRVSIALK KTSEILHDID CLLSNSKK