ID   CE049_HUMAN             Reviewed;         147 AA.
AC   A4QMS7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Uncharacterized protein C5orf49;
GN   Name=C5orf49;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       A4QMS7; P55273: CDKN2D; NbExp=3; IntAct=EBI-12039847, EBI-745859;
CC       A4QMS7; O75031: HSF2BP; NbExp=3; IntAct=EBI-12039847, EBI-7116203;
CC       A4QMS7; Q15323: KRT31; NbExp=3; IntAct=EBI-12039847, EBI-948001;
CC       A4QMS7; O76011: KRT34; NbExp=3; IntAct=EBI-12039847, EBI-1047093;
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DR   EMBL; CH471102; EAX08096.1; -; Genomic_DNA.
DR   EMBL; BC104205; AAI04206.1; -; mRNA.
DR   EMBL; BC115361; AAI15362.1; -; mRNA.
DR   CCDS; CCDS43300.1; -.
DR   RefSeq; NP_001083053.1; NM_001089584.2.
DR   AlphaFoldDB; A4QMS7; -.
DR   BioGRID; 126385; 4.
DR   IntAct; A4QMS7; 4.
DR   STRING; 9606.ENSP00000382708; -.
DR   iPTMnet; A4QMS7; -.
DR   PhosphoSitePlus; A4QMS7; -.
DR   BioMuta; C5orf49; -.
DR   MassIVE; A4QMS7; -.
DR   PaxDb; A4QMS7; -.
DR   PeptideAtlas; A4QMS7; -.
DR   PRIDE; A4QMS7; -.
DR   ProteomicsDB; 684; -.
DR   Antibodypedia; 64337; 38 antibodies from 8 providers.
DR   DNASU; 134121; -.
DR   Ensembl; ENST00000399810.7; ENSP00000382708.2; ENSG00000215217.7.
DR   GeneID; 134121; -.
DR   KEGG; hsa:134121; -.
DR   MANE-Select; ENST00000399810.7; ENSP00000382708.2; NM_001089584.3; NP_001083053.1.
DR   UCSC; uc003jea.7; human.
DR   CTD; 134121; -.
DR   GeneCards; C5orf49; -.
DR   HGNC; HGNC:27028; C5orf49.
DR   HPA; ENSG00000215217; Tissue enhanced (brain, fallopian tube, testis).
DR   neXtProt; NX_A4QMS7; -.
DR   OpenTargets; ENSG00000215217; -.
DR   PharmGKB; PA162380347; -.
DR   VEuPathDB; HostDB:ENSG00000215217; -.
DR   eggNOG; ENOG502S3H1; Eukaryota.
DR   GeneTree; ENSGT00390000015121; -.
DR   HOGENOM; CLU_127177_0_0_1; -.
DR   InParanoid; A4QMS7; -.
DR   OMA; CDREHAK; -.
DR   OrthoDB; 1553723at2759; -.
DR   PhylomeDB; A4QMS7; -.
DR   TreeFam; TF328385; -.
DR   PathwayCommons; A4QMS7; -.
DR   SignaLink; A4QMS7; -.
DR   BioGRID-ORCS; 134121; 13 hits in 1034 CRISPR screens.
DR   ChiTaRS; C5orf49; human.
DR   GenomeRNAi; 134121; -.
DR   Pharos; A4QMS7; Tdark.
DR   PRO; PR:A4QMS7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A4QMS7; protein.
DR   Bgee; ENSG00000215217; Expressed in right uterine tube and 98 other tissues.
DR   ExpressionAtlas; A4QMS7; baseline and differential.
DR   Genevisible; A4QMS7; HS.
DR   GO; GO:0036064; C:ciliary basal body; IDA:GO_Central.
DR   InterPro; IPR027901; DUF4541.
DR   PANTHER; PTHR34444; PTHR34444; 1.
DR   Pfam; PF15074; DUF4541; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..147
FT                   /note="Uncharacterized protein C5orf49"
FT                   /id="PRO_0000336090"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         68
FT                   /note="Q -> H (in dbSNP:rs6883562)"
FT                   /id="VAR_043546"
FT   VARIANT         87
FT                   /note="E -> K (in dbSNP:rs16879215)"
FT                   /id="VAR_043547"
FT   VARIANT         139
FT                   /note="P -> S (in dbSNP:rs326181)"
FT                   /id="VAR_043548"
SQ   SEQUENCE   147 AA;  16991 MW;  7062F33544448479 CRC64;
     MEDDEEETTA STLRGKPRPP PVSAQSAFSY IPPRRLDPKE HSYYYRPART GIISLYDCIF
     KRRLDYDQKL HRDDREHAKS LGLHVNEEEQ ERPVGVLTSS VYGKRINQPI EPLNRDFGRA
     NHVQADFYRK NDIPSLKEPG FGHIAPS