CE049_MOUSE
ID CE049_MOUSE Reviewed; 182 AA.
AC Q9DAR0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized protein C5orf49 homolog;
DE AltName: Full=Y regulated sperm protein;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RC STRAIN=RIII; TISSUE=Sperm;
RA Bhattacharya R., Dhople V.M., Jesudasan R.A.;
RT "Novel miRNA cluster generated by extensive alternate splicing of a
RT multicopy non-coding RNA from mouse Y-heterochromatin.";
RL Submitted (JUN-2009) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in sperm (at protein level).
CC {ECO:0000269|Ref.3}.
CC -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 7.7,
CC its MW is: 22 kDa.
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DR EMBL; AK005609; BAB24148.1; -; mRNA.
DR EMBL; AK138387; BAE23640.1; -; mRNA.
DR EMBL; BC119515; AAI19516.1; -; mRNA.
DR EMBL; BC119516; AAI19517.1; -; mRNA.
DR CCDS; CCDS49306.1; -.
DR RefSeq; NP_081311.1; NM_027035.1.
DR AlphaFoldDB; Q9DAR0; -.
DR STRING; 10090.ENSMUSP00000022007; -.
DR PhosphoSitePlus; Q9DAR0; -.
DR PaxDb; Q9DAR0; -.
DR PRIDE; Q9DAR0; -.
DR Antibodypedia; 64337; 38 antibodies from 8 providers.
DR Ensembl; ENSMUST00000022007; ENSMUSP00000022007; ENSMUSG00000021534.
DR Ensembl; ENSMUST00000222604; ENSMUSP00000152877; ENSMUSG00000021534.
DR GeneID; 69315; -.
DR KEGG; mmu:69315; -.
DR UCSC; uc007rcd.2; mouse.
DR MGI; MGI:1916565; 1700001L19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000021534; -.
DR eggNOG; ENOG502S3H1; Eukaryota.
DR GeneTree; ENSGT00390000015121; -.
DR HOGENOM; CLU_127177_0_0_1; -.
DR InParanoid; Q9DAR0; -.
DR OMA; CDREHAK; -.
DR OrthoDB; 1372130at2759; -.
DR PhylomeDB; Q9DAR0; -.
DR TreeFam; TF328385; -.
DR BioGRID-ORCS; 69315; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9DAR0; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9DAR0; protein.
DR Bgee; ENSMUSG00000021534; Expressed in spermatid and 65 other tissues.
DR Genevisible; Q9DAR0; MM.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR InterPro; IPR027901; DUF4541.
DR PANTHER; PTHR34444; PTHR34444; 1.
DR Pfam; PF15074; DUF4541; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..182
FT /note="Uncharacterized protein C5orf49 homolog"
FT /id="PRO_0000336091"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 20848 MW; 8C2AD0F38352C9ED CRC64;
MEELAKKERR AMDPGGLKKE GKVEEEAGKE EGREEEGGEE EEVTSETLRG KPRPLPISAL
PAFSYIPPRH QGPKERSYFS REGQTGIVSL YDCVFKRRLD YNQKLHRDDR EHAKNLGLHI
NEEEQERTVP VLMSSVYGKR INQPIEPLNR DYGHVSHVKT DFYRKNEIPS IKGPGFGHIN
PA
