CE060_HUMAN
ID CE060_HUMAN Reviewed; 353 AA.
AC A6NFR6; A1L488; B7ZM52; B7ZM53;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Uncharacterized protein C5orf60;
GN Name=C5orf60;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND VARIANT
RP GLU-70 DEL.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A6NFR6-4; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10173955, EBI-10172181;
CC A6NFR6-4; Q15323: KRT31; NbExp=3; IntAct=EBI-10173955, EBI-948001;
CC A6NFR6-4; Q6A162: KRT40; NbExp=3; IntAct=EBI-10173955, EBI-10171697;
CC A6NFR6-4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10173955, EBI-10172052;
CC A6NFR6-4; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10173955, EBI-751260;
CC A6NFR6-4; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10173955, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A6NFR6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NFR6-2; Sequence=VSP_034519, VSP_034520;
CC Name=3;
CC IsoId=A6NFR6-3; Sequence=VSP_038832, VSP_038833;
CC Name=4;
CC IsoId=A6NFR6-4; Sequence=VSP_041195, VSP_041196;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI30443.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI30445.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC136604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130442; AAI30443.1; ALT_INIT; mRNA.
DR EMBL; BC130444; AAI30445.1; ALT_INIT; mRNA.
DR EMBL; BC144274; AAI44275.1; -; mRNA.
DR EMBL; BC144275; AAI44276.1; -; mRNA.
DR RefSeq; NP_001135778.1; NM_001142306.2. [A6NFR6-4]
DR RefSeq; NP_001292317.1; NM_001305388.1. [A6NFR6-2]
DR RefSeq; XP_011532836.1; XM_011534534.2.
DR AlphaFoldDB; A6NFR6; -.
DR SMR; A6NFR6; -.
DR BioGRID; 130177; 8.
DR IntAct; A6NFR6; 6.
DR iPTMnet; A6NFR6; -.
DR PhosphoSitePlus; A6NFR6; -.
DR BioMuta; C5orf60; -.
DR MassIVE; A6NFR6; -.
DR PaxDb; A6NFR6; -.
DR PeptideAtlas; A6NFR6; -.
DR PRIDE; A6NFR6; -.
DR ProteomicsDB; 1070; -. [A6NFR6-1]
DR ProteomicsDB; 1071; -. [A6NFR6-2]
DR ProteomicsDB; 1072; -. [A6NFR6-3]
DR ProteomicsDB; 1073; -. [A6NFR6-4]
DR DNASU; 285679; -.
DR GeneID; 285679; -.
DR UCSC; uc063kop.1; human. [A6NFR6-1]
DR CTD; 285679; -.
DR GeneCards; C5orf60; -.
DR HGNC; HGNC:27753; C5orf60.
DR neXtProt; NX_A6NFR6; -.
DR PharmGKB; PA165660205; -.
DR eggNOG; ENOG502TE66; Eukaryota.
DR InParanoid; A6NFR6; -.
DR OrthoDB; 974943at2759; -.
DR PhylomeDB; A6NFR6; -.
DR PathwayCommons; A6NFR6; -.
DR SignaLink; A6NFR6; -.
DR BioGRID-ORCS; 285679; 10 hits in 954 CRISPR screens.
DR GenomeRNAi; 285679; -.
DR Pharos; A6NFR6; Tdark.
DR PRO; PR:A6NFR6; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NFR6; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..353
FT /note="Uncharacterized protein C5orf60"
FT /id="PRO_0000342655"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 122..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 229..281
FT /note="YLSSLSSSQPPEPLRPLKHPSHKPRGRSLPRRRNPGWVSWSDSMQADSETDT
FT I -> LPSRETPHAGRWRQGSRFPQPGCANAAGRIRHQNPRHSHGHRISDIHEQLGIS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034519"
FT VAR_SEQ 229..277
FT /note="YLSSLSSSQPPEPLRPLKHPSHKPRGRSLPRRRNPGWVSWSDSMQADSE ->
FT ETPHAGRWRQGSRFPQPGCANAAGRIRHQNPRHSHGHRISDIHEQLGIS (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_041195"
FT VAR_SEQ 229..237
FT /note="YLSSLSSSQ -> LDVPTLLDA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038832"
FT VAR_SEQ 238..353
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038833"
FT VAR_SEQ 278..353
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_041196"
FT VAR_SEQ 282..353
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034520"
FT VARIANT 55
FT /note="R -> C (in dbSNP:rs1319931)"
FT /id="VAR_044323"
FT VARIANT 56
FT /note="L -> P (in dbSNP:rs13168357)"
FT /id="VAR_044324"
FT VARIANT 70
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062961"
SQ SEQUENCE 353 AA; 39250 MW; E9FA509E61B72918 CRC64;
MPRAQLPEDS SAVDMDILFP LDSVIGTELC PSPIPQIIHF VLFVVFSLVI LIILRLYIPR
EPSSVPPREE DSENDQAEVG EWLRIGNKYI TLKDYRILLK ELENLEIYTF LSKKCLKKLS
REGSSHHLPR QVRPGPVYKP APARNHRPRG GRGKASPTSF HVSPRAPLAP LASMPSSVPK
TSVESLGSPS SLSSSKPREP LCPLKHPSHQ PPASTLSPNP TSSTESLGYL SSLSSSQPPE
PLRPLKHPSH KPRGRSLPRR RNPGWVSWSD SMQADSETDT IICPMCKAPE RSCPHTWWVP
SSPRVIRGVG RCSDPNLGLS WRQEAARAWC HCTSSQFPFK HPNLPTHLPK ASF
