ID   CE064_HUMAN             Reviewed;         130 AA.
AC   Q2M2E5; Q2M2H1; Q8N1U8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Uncharacterized protein C5orf64;
DE   Flags: Precursor;
GN   Name=C5orf64;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Caudate nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-57 AND TRP-101.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AK094862; BAC04439.1; -; mRNA.
DR   EMBL; CH471137; EAW51393.1; -; Genomic_DNA.
DR   EMBL; BC112008; AAI12009.1; -; mRNA.
DR   EMBL; BC111982; AAI11983.1; -; mRNA.
DR   RefSeq; NP_775938.1; NM_173667.3.
DR   AlphaFoldDB; Q2M2E5; -.
DR   BioGRID; 130173; 6.
DR   IntAct; Q2M2E5; 2.
DR   STRING; 9606.ENSP00000485493; -.
DR   iPTMnet; Q2M2E5; -.
DR   PhosphoSitePlus; Q2M2E5; -.
DR   BioMuta; HGNC:26744; -.
DR   PaxDb; Q2M2E5; -.
DR   PRIDE; Q2M2E5; -.
DR   ProteomicsDB; 61351; -.
DR   GeneCards; C5orf64; -.
DR   HGNC; HGNC:26744; C5orf64.
DR   neXtProt; NX_Q2M2E5; -.
DR   eggNOG; ENOG502TECM; Eukaryota.
DR   InParanoid; Q2M2E5; -.
DR   OrthoDB; 1474854at2759; -.
DR   PhylomeDB; Q2M2E5; -.
DR   TreeFam; TF342450; -.
DR   PathwayCommons; Q2M2E5; -.
DR   SignaLink; Q2M2E5; -.
DR   BioGRID-ORCS; 285668; 10 hits in 1043 CRISPR screens.
DR   ChiTaRS; C5orf64; human.
DR   GenomeRNAi; 285668; -.
DR   Pharos; Q2M2E5; Tdark.
DR   PRO; PR:Q2M2E5; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q2M2E5; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..130
FT                   /note="Uncharacterized protein C5orf64"
FT                   /id="PRO_0000339305"
FT   VARIANT         57
FT                   /note="A -> T (in dbSNP:rs16893687)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_043940"
FT   VARIANT         101
FT                   /note="R -> W (in dbSNP:rs436696)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_043941"
SQ   SEQUENCE   130 AA;  14817 MW;  74D9BF93D7B16D3B CRC64;
     MLAPLFLCCL RNLFRKLISF QPPQLGRTNM HYSKLPRTAI ETEFKQNVGP PPKDLTAEVY
     FPSIKSRSHL PAVFYNQYFK HPKCVGEYGP KNGAERQIEE RKVLPTTMMF SMLADCVLKS
     TPIPILGVAM