CE104_MOUSE
ID CE104_MOUSE Reviewed; 926 AA.
AC Q80V31; B1AX97; Q6ZQ95;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Centrosomal protein of 104 kDa;
DE Short=Cep104;
GN Name=Cep104; Synonyms=Kiaa0562;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-926.
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- FUNCTION: Required for ciliogenesis and for structural integrity at the
CC ciliary tip. {ECO:0000250|UniProtKB:O60308}.
CC -!- SUBUNIT: Interacts with CCP110 and CEP97. Interacts with ARMC9,
CC TOGARAM1, CCDC66 and CSPP1. {ECO:0000250|UniProtKB:O60308}.
CC -!- INTERACTION:
CC Q80V31; Q15637: SF1; Xeno; NbExp=3; IntAct=EBI-11073001, EBI-744603;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:O60308}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:O60308}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:O60308}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:O60308}.
CC Note=In interphase non-ciliated cells, localizes to the distal ends of
CC both the mother and daughter centrioles. In ciliated cells, present at
CC the distal end of the daughter centriole, but not on the mother
CC centriole, and at the tip of primary cilium. Localization at the
CC ciliary tip is also observed in motile cilia. Throughout S phase,
CC associated with both mother and daughter centrioles in each centrosome.
CC During metaphase and telophase, present at both spindle poles.
CC {ECO:0000250|UniProtKB:O60308}.
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DR EMBL; AL806525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046331; AAH46331.1; -; mRNA.
DR EMBL; AK129163; BAC97973.1; -; mRNA.
DR CCDS; CCDS19005.1; -.
DR RefSeq; NP_808341.1; NM_177673.2.
DR AlphaFoldDB; Q80V31; -.
DR SMR; Q80V31; -.
DR BioGRID; 231061; 9.
DR IntAct; Q80V31; 7.
DR STRING; 10090.ENSMUSP00000040762; -.
DR iPTMnet; Q80V31; -.
DR PhosphoSitePlus; Q80V31; -.
DR MaxQB; Q80V31; -.
DR PaxDb; Q80V31; -.
DR PRIDE; Q80V31; -.
DR ProteomicsDB; 281155; -.
DR Antibodypedia; 26970; 102 antibodies from 16 providers.
DR DNASU; 230967; -.
DR Ensembl; ENSMUST00000047497; ENSMUSP00000040762; ENSMUSG00000039523.
DR GeneID; 230967; -.
DR KEGG; mmu:230967; -.
DR UCSC; uc008wax.1; mouse.
DR CTD; 9731; -.
DR MGI; MGI:2687282; Cep104.
DR VEuPathDB; HostDB:ENSMUSG00000039523; -.
DR eggNOG; KOG4825; Eukaryota.
DR GeneTree; ENSGT00390000013405; -.
DR HOGENOM; CLU_003200_0_0_1; -.
DR InParanoid; Q80V31; -.
DR OMA; VQGNDYN; -.
DR OrthoDB; 242784at2759; -.
DR PhylomeDB; Q80V31; -.
DR TreeFam; TF323766; -.
DR BioGRID-ORCS; 230967; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cep104; mouse.
DR PRO; PR:Q80V31; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80V31; protein.
DR Bgee; ENSMUSG00000039523; Expressed in olfactory epithelium and 232 other tissues.
DR ExpressionAtlas; Q80V31; baseline and differential.
DR Genevisible; Q80V31; MM.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0016595; F:glutamate binding; ISO:MGI.
DR GO; GO:0016594; F:glycine binding; ISO:MGI.
DR GO; GO:0016596; F:thienylcyclohexylpiperidine binding; ISO:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 1: Evidence at protein level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat.
FT CHAIN 1..926
FT /note="Centrosomal protein of 104 kDa"
FT /id="PRO_0000050764"
FT REPEAT 522..558
FT /note="HEAT 1"
FT REPEAT 603..639
FT /note="HEAT 2"
FT REGION 345..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 212..279
FT /evidence="ECO:0000255"
FT COILED 678..730
FT /evidence="ECO:0000255"
FT COMPBIAS 394..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 103946 MW; 7B7822A0284F3C3F CRC64;
MPHKIGFVVV SSSGHEDGFS ARELMIHAPT VSGWRSPKFC QFPQEIVLQM VERCRVRKLQ
LLAHQYMISS KVEFYISESL PEYLVPYQAE RFRRLGYVSL CDNEKTGCKA RELKSVYVDA
VGQFLKLIFH QNHANKYNIY NQVALVAINI IGDPADLGDE SNITSREKLI DHYLGHSPHN
PEDPALDGTF SGRSDYISPL DDLAFDMYQD PEVAQIIRRL DERKREAVKK ERYDHAKKLK
QAIADLQKVG ERLGRYEVEK RCAVEKEDYD LAKEKKQQMA RYRAQVYEQL ELHGLLQGEP
EMQRPFALPL QPLASPSSPQ HWKAVSSLPR TEKLVAEDSF AGPVLQEKPS ASSPQHSAVD
PSPPAAGHAP RSHTEVLPYD ERPLPVTRKQ LGEASAEAEV KEADSDVRRR GVAGEPEPLT
EKALREASAA IDTLGEALVA GAYSKMWSCR EDALLALYKK LMEMPVGTQK EDLKNMLRAS
VFLIRRAIKD IVASVFQASL KLLKMIITQY IPKHKLGKLD TTHCVERAFP LLLARAGDSS
ARLRVMALNF IQEMALFKEV KSLQLIPSYL VQPLKANASV HLAMSQVDLL ARLLRDLGTE
SSGFTVDNVM KFAVSALEHR VYEVRETAVR IILDMYRQHP ALTLEHLPPD DSATRRNLLY
KAIFEGFAKI DGSVLPTEAE VRAQKRVATK EAEKQKKEEM KALQGQSGEL RETQAGVQEK
ESEAVKLRNQ DPQGRKAVLP DTPEIPANHF LDNLCIFCGE RNESFTEEGL DLHYWKHCLM
LTRCDHCRQV VEISSLTEHL LTECDRRDGF GKCPRCSEAI PKEELPGHIK TKECSPAKPE
KVANHCPLCH ENFAPGEEAW KVHLMGPAGC TMNLRKTHVL YKATAPQQGK GPAAAKSSTS
APKVGSKIPT PKGGLSKSSS RTYMRR
