CE112_MOUSE
ID CE112_MOUSE Reviewed; 954 AA.
AC Q5PR68; Q80ZN6; Q99JS4; Q9D9T1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Centrosomal protein of 112 kDa;
DE Short=Cep112;
DE AltName: Full=Coiled-coil domain-containing protein 46;
GN Name=Cep112; Synonyms=Ccdc46;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 79-285 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 188-954 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, Mammary gland, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-206 (ISOFORM 1).
RX PubMed=11544199; DOI=10.1101/gr.185501;
RA Piao Y., Ko N.T., Lim M.K., Ko M.S.H.;
RT "Construction of long-transcript enriched cDNA libraries from submicrogram
RT amounts of total RNAs by a universal PCR amplification method.";
RL Genome Res. 11:1553-1558(2001).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Note=Localizes around spindle poles
CC in some cells. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5PR68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5PR68-2; Sequence=VSP_018340, VSP_018341;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH86808.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK006504; BAB24623.1; -; mRNA.
DR EMBL; CF900073; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL935172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005723; AAH05723.1; -; mRNA.
DR EMBL; BC048677; AAH48677.1; -; mRNA.
DR EMBL; BC086808; AAH86808.1; ALT_INIT; mRNA.
DR EMBL; BB255707; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS36359.1; -. [Q5PR68-1]
DR CCDS; CCDS48966.1; -. [Q5PR68-2]
DR RefSeq; NP_083862.1; NM_029586.2.
DR RefSeq; NP_083882.3; NM_029606.3. [Q5PR68-1]
DR RefSeq; NP_663721.2; NM_145688.2. [Q5PR68-2]
DR RefSeq; XP_011247602.1; XM_011249300.2.
DR AlphaFoldDB; Q5PR68; -.
DR BioGRID; 218090; 3.
DR STRING; 10090.ENSMUSP00000102326; -.
DR iPTMnet; Q5PR68; -.
DR PhosphoSitePlus; Q5PR68; -.
DR MaxQB; Q5PR68; -.
DR PaxDb; Q5PR68; -.
DR PRIDE; Q5PR68; -.
DR ProteomicsDB; 281363; -. [Q5PR68-1]
DR ProteomicsDB; 281364; -. [Q5PR68-2]
DR Antibodypedia; 19170; 132 antibodies from 24 providers.
DR DNASU; 76380; -.
DR Ensembl; ENSMUST00000061287; ENSMUSP00000050597; ENSMUSG00000020728. [Q5PR68-1]
DR Ensembl; ENSMUST00000106715; ENSMUSP00000102326; ENSMUSG00000020728. [Q5PR68-2]
DR Ensembl; ENSMUST00000130515; ENSMUSP00000114569; ENSMUSG00000020728. [Q5PR68-1]
DR GeneID; 76380; -.
DR KEGG; mmu:76380; -.
DR UCSC; uc007mbr.1; mouse. [Q5PR68-1]
DR UCSC; uc007mbs.1; mouse. [Q5PR68-2]
DR CTD; 201134; -.
DR MGI; MGI:1923673; Cep112.
DR VEuPathDB; HostDB:ENSMUSG00000020728; -.
DR eggNOG; ENOG502QQAE; Eukaryota.
DR GeneTree; ENSGT00390000006544; -.
DR HOGENOM; CLU_131263_0_0_1; -.
DR InParanoid; Q5PR68; -.
DR OMA; WEKRLHD; -.
DR OrthoDB; 1483821at2759; -.
DR PhylomeDB; Q5PR68; -.
DR TreeFam; TF328995; -.
DR BioGRID-ORCS; 76380; 5 hits in 69 CRISPR screens.
DR ChiTaRS; Cep112; mouse.
DR PRO; PR:Q5PR68; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5PR68; protein.
DR Bgee; ENSMUSG00000020728; Expressed in spermatid and 233 other tissues.
DR ExpressionAtlas; Q5PR68; baseline and differential.
DR Genevisible; Q5PR68; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060077; C:inhibitory synapse; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0097120; P:receptor localization to synapse; ISO:MGI.
DR InterPro; IPR027831; DUF4485.
DR Pfam; PF14846; DUF4485; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..954
FT /note="Centrosomal protein of 112 kDa"
FT /id="PRO_0000234509"
FT COILED 276..954
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..781
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_018340"
FT VAR_SEQ 782..797
FT /note="ELKKTHAAETEMTLEK -> MRPLRDTGPSVPKENM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_018341"
SQ SEQUENCE 954 AA; 112676 MW; 0959856DDD0D6A7F CRC64;
METGSEEEKW EKLDAEFDHF VVDMKPFVLK LPHRSERQRC ALWIRKLCEP SGTGAGLMGR
KNRNLYAKLL LHMLRRGILE GPFTHRPEPG TLKTLPSYMS IYFDEPNQAQ PKDSSPEKLP
DWVRGELQTG EQRLSDSWQC SSGEDNTLVL AASDAHREQY TGKLRMRSHS VSPTYREDKQ
HITSKICEVH SKTSPISLDD SDIEVRLNSW NLGIENPRYL RQKPLPVSLM TPKGSLRKAS
SLHDDHFLSR MHEKELDMKT KMMEAKFSEE KLKLQQKHDA EVQKILERKN NELEELKILY
KKKQTETEET IRKLEKKVQI LIRDCQVIRE TKENQITELK KICEQSTESL NNDWEKKLHN
AVAEMEKDKF ELQKHHTETI QELLEDTNVR LSKMEADYVV QMQSTNHMIK ELEGRVQQLM
GEAENSNLQR QKLTQEKLEL ERCYQITCNE LQELKTRRNI LHKEKEHLVN DYEQNVKLLK
TKYDSDINLL RQEHALSTSK TSGVIEELEQ NICQLKQQVQ ESELQRKQQV KDQENKFHME
KNHLKHTYEK KVHELQSELD KEKEDAQRKI HKFEEALKEK EEQLSRVTEV QRLQAQQADA
ALEEFKRQVE VNSEKVYGEM KEQMEKVEAD LTRSKSLREK QSKEFLWQLE DAKQRYEQQI
VELKLEHEQE KTHLLQQHSA EKDSLVRDHD REIENLEKQL RAANMEHENQ IQESKKRDAQ
VIADMEAQVH KLREELISVN SQRKQQLIEL GLLREEEKQR AAKDHETAVK KLKAESERVK
MELKKTHAAE TEMTLEKANS RLKQIEKEYT QKLAKSSQII AELQTTISSL KEESSRQQLA
AERRLQDVIQ KFEDEKQQLI RDNDQAIKAL QDELETRSHQ VRSAEKKLHH KELEAQEQIM
YIRQEYETKF KGLMPASLRQ ELEDTISSLK SQVNFLQKRA SILQEELTTY QSRR
