ID   CE120_XENTR             Reviewed;         882 AA.
AC   B1H2P5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Centrosomal protein of 120 kDa;
DE            Short=Cep120;
DE   AltName: Full=Coiled-coil domain-containing protein 100;
GN   Name=cep120; Synonyms=ccdc100;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the microtubule-dependent coupling of the
CC       nucleus and the centrosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP120 family. {ECO:0000305}.
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DR   EMBL; BC161079; AAI61079.1; -; mRNA.
DR   RefSeq; NP_001120380.1; NM_001126908.1.
DR   AlphaFoldDB; B1H2P5; -.
DR   SMR; B1H2P5; -.
DR   STRING; 8364.ENSXETP00000057155; -.
DR   GeneID; 100145455; -.
DR   KEGG; xtr:100145455; -.
DR   CTD; 153241; -.
DR   Xenbase; XB-GENE-5872143; cep120.
DR   eggNOG; ENOG502QPT0; Eukaryota.
DR   InParanoid; B1H2P5; -.
DR   OrthoDB; 277001at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; IBA:GO_Central.
DR   GO; GO:0022027; P:interkinetic nuclear migration; IBA:GO_Central.
DR   GO; GO:1903724; P:positive regulation of centriole elongation; IBA:GO_Central.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039893; CEP120-like.
DR   InterPro; IPR022136; DUF3668.
DR   PANTHER; PTHR21574; PTHR21574; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF12416; DUF3668; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..882
FT                   /note="Centrosomal protein of 120 kDa"
FT                   /id="PRO_0000348264"
FT   DOMAIN          1..112
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          453..582
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          348..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          709..882
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   882 AA;  100324 MW;  CC4FDBC47BF1E443 CRC64;
     MGYKSDQLLI VVSILEGRHF PKRSRHMLVI DAKFDGEQLS TDPVPHLEQP QFATELAWEL
     DRKTLHQHRL QRTPIKLQCF ALDTLTSAKE SVGYVVLDLR AAQEKKQAPK WYSLLSSKYT
     KFKPEIQLNI SLETDNKPAV DTFKAKEAPP RRSKVPGDLA GLEPKSLVPI LNEAEGYHQI
     GPAEYCKDYF VLSVTIAFAT QLEQLIPSTL RLPEPQPEFF FYYSLLGNDV TNEPFTDLIN
     PEFEPERASV RIRSSKEVLC MYLSVQPKLQ IHLCCGDQSL GSTDIALTGL LNKASVEIEH
     HPVVVEGAFI LTPPNRAKQN LSAVPLEMSP TIGVSIALQK EIGLQSVHHP KEQPQSVAAE
     EVPTTPLKKS ANLKEGARSP PPPKPLMFSD SPPTKDEATE SEAESIKSDF QAEPPLSKPL
     TRSKSPPLSE PPLSGSHCPT PIQGVSAIAK NTSESSSAQK ITVPPAAHHF CFTIDLRSIR
     NVDVGFPVNC ILRYSYPFFG SAAPIMTNPP VEVQKNMEVF LPQSYCAFDF ATLPHQIQDT
     FLRLPLLVEL WHKDKMTKDL LIGVTKIQLS NVLSSEKTRF LGPHGDQCWR QTFSERITVT
     AVEGSKNKVA ELSYIITLED YGLVKVREVV VSESSQSTGQ EKGSLPAQTL QSTAPLPEPR
     ETLEYKAALE LEMWKEMQED LFVNQLKKKE LVHMQALAEE WKRRDKEREA LVKKKVAEYT
     VLEEQLQKAL ADLEKRERQL ANDEMELKKL KAQMQLDCER SIQERQDSIR RVREDCMHQI
     ELERSKAKQL EEDKLRLQQQ VELERKLEST TKSKLHYKQQ WGRALKELAR LKQREQENAM
     ARLKKQQQEL EHMRLRYLAA EEKDVVKTER QELEEIRNEL NR