CE126_MOUSE
ID CE126_MOUSE Reviewed; 1103 AA.
AC Q0VBV7; Q6ZPS8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Centrosomal protein of 126 kDa {ECO:0000312|MGI:MGI:2680221};
GN Name=Cep126 {ECO:0000312|MGI:MGI:2680221}; Synonyms=Kiaa1377;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-1103.
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- FUNCTION: Participate in cytokinesis (By similarity). Necessary for
CC microtubules and mitotic spindle organization (By similarity). Involved
CC in primary cilium formation (By similarity).
CC {ECO:0000250|UniProtKB:Q9P2H0}.
CC -!- SUBUNIT: Interacts with DCTN1 (By similarity).
CC {ECO:0000250|UniProtKB:Q9P2H0}.
CC -!- SUBCELLULAR LOCATION: Midbody {ECO:0000250|UniProtKB:Q9P2H0}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q9P2H0}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q9P2H0}.
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DR EMBL; BC119072; AAI19073.1; -; mRNA.
DR EMBL; BC120489; AAI20490.1; -; mRNA.
DR EMBL; AK129341; BAC98151.1; -; mRNA.
DR CCDS; CCDS40534.1; -.
DR RefSeq; NP_001038989.1; NM_001045524.1.
DR AlphaFoldDB; Q0VBV7; -.
DR SMR; Q0VBV7; -.
DR BioGRID; 231601; 3.
DR STRING; 10090.ENSMUSP00000042904; -.
DR iPTMnet; Q0VBV7; -.
DR PhosphoSitePlus; Q0VBV7; -.
DR MaxQB; Q0VBV7; -.
DR PaxDb; Q0VBV7; -.
DR PRIDE; Q0VBV7; -.
DR ProteomicsDB; 280046; -.
DR Antibodypedia; 51505; 32 antibodies from 7 providers.
DR Ensembl; ENSMUST00000037397; ENSMUSP00000042904; ENSMUSG00000040729.
DR GeneID; 234915; -.
DR KEGG; mmu:234915; -.
DR UCSC; uc009odj.1; mouse.
DR CTD; 57562; -.
DR MGI; MGI:2680221; Cep126.
DR VEuPathDB; HostDB:ENSMUSG00000040729; -.
DR eggNOG; ENOG502QR78; Eukaryota.
DR GeneTree; ENSGT00390000013786; -.
DR HOGENOM; CLU_010202_0_0_1; -.
DR InParanoid; Q0VBV7; -.
DR OrthoDB; 99309at2759; -.
DR PhylomeDB; Q0VBV7; -.
DR TreeFam; TF336632; -.
DR BioGRID-ORCS; 234915; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q0VBV7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q0VBV7; protein.
DR Bgee; ENSMUSG00000040729; Expressed in spermatid and 161 other tissues.
DR ExpressionAtlas; Q0VBV7; baseline and differential.
DR Genevisible; Q0VBV7; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0097546; C:ciliary base; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:InterPro.
DR InterPro; IPR028257; CEP126.
DR PANTHER; PTHR31191; PTHR31191; 1.
DR Pfam; PF15352; K1377; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..1103
FT /note="Centrosomal protein of 126 kDa"
FT /id="PRO_0000295172"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 43..116
FT /evidence="ECO:0000255"
FT COILED 182..222
FT /evidence="ECO:0000255"
FT COMPBIAS 725..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 123685 MW; AF5C4D62101FC7D3 CRC64;
MLAGRPGAQS AGAGVGAGPP DAPGARDGGG RPRPGAYLDM KIHLEKNLEE ERQMLLQQQK
LCRNRARKYF MESNRRRKAF EEKRQKQEER EYQIRERILQ QRKQKFEEVT EKFQRAHVPV
SQRRRAVFQN PVPPLEEALK QIQESNLKSE VNIPLFHRPA TNWRAIDSAL PSTLSKNDHK
HQKHLVRRIN RNKEMKENNI ANLATNKNVF QLKLEETQKL LEDQHLSDLQ KFCDEVNQIT
NSETLSSIDS LEAGEREEIY ITLSMKPSTS TQQNSVPLQS ANLQAAHLDC FDEDKLSFSK
TQHINNWLTN LDAQNSQPVA SFSDILIKSN VLPSWECLNS KEQNPPALSR TVGRTTRTTS
DSMVFVCSPS VVALDKKGEN TAESNVVRAS DPTEGAVQRE RPAQMESPTF KVSRAWTTAE
SLTQETASFS VQERPSELTW ESRTASIPAS SVTVLSPNLQ AGGPLAENNT QIKEIDPVQC
SDKLDELKNM EHERINHLNC NKEKYLFSPN FQTTCALQNS NSNDRKQKES GPSAALCNNP
PDCDLPEQHS IKHSVHEQNG VRLLKSILKK ESRYEHNYLR ALVMKQGFKF RHQKAETVRD
SIELTKQKGK GAEISKTSKK LRWFDESANL ENAVDDCHPV RNRAGMAPRW LQRCHTNSGT
YNLTSIPECP VHSAAGKKAK ADSVPENATD LGRYEIDSVP LNSSVSLGFS FAKQAWSACR
RGESKAPVHA SDSKTQKTKP QRGVKFTRRT GSSKVQKGLV QNRKPTVSQP QTSSKANTVA
QTQGKLIITH PPPKPPTNIK SGKNMQVSPG QSAIPEHSQN VMTQSCLSPA SVLPTEYHLN
QGTQESSLPF SDTCSNLPAV SPALPTPYSS ECQTLAKANS NGTAFLKDGA VYCTHRSPVC
EESYQSFTHR NTEEESILPW RRRINGHQNE RTTDSTVTRR KQIVENKWKR LLEQKRKTSG
SIGMKYTEQI THFGQNVPPS TTEQIQAPRG VKTEEVSDST SEFLVAENLM NSSVPEDEIL
TAINSKHLQK PNLSQPTNVC ALSAEEQKIL KSLHHLDERL YYVQEAIRKN PSIKNTLQLI
PLLSSQPRAS LSPDVGSTVQ RKY
