ID   CE152_XENLA             Reviewed;        1663 AA.
AC   Q498G2;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Centrosomal protein of 152 kDa;
DE            Short=Cep152;
GN   Name=cep152;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=24075808; DOI=10.1016/j.devcel.2013.08.021;
RA   Klos Dehring D.A., Vladar E.K., Werner M.E., Mitchell J.W., Hwang P.,
RA   Mitchell B.J.;
RT   "Deuterosome-mediated centriole biogenesis.";
RL   Dev. Cell 27:103-112(2013).
CC   -!- FUNCTION: Necessary for centrosome duplication; the function seems also
CC       to involve cep63, cdk5rap2 and wdr62 through a stepwise assembled
CC       complex at the centrosome that recruits cdk2 required for centriole
CC       duplication. Acts as a molecular scaffold facilitating the interaction
CC       of plk4 and cenpj, 2 molecules involved in centriole formation (By
CC       similarity). Also plays a key role in deuterosome-mediated centriole
CC       amplification in multiciliated that can generate more than 100
CC       centrioles (PubMed:24075808). Overexpression of cep152 can drive
CC       amplification of centrioles (By similarity).
CC       {ECO:0000250|UniProtKB:O94986, ECO:0000269|PubMed:24075808}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:24075808}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:O94986}. Note=Colocalizes with cdk5rap2, wdr62
CC       and cep63 in a discrete ring around the proximal end of the parental
CC       centriole. At this site, a cohesive structure is predicted to engage
CC       parental centrioles and procentrioles (By similarity). Localizes to the
CC       deuterosome (PubMed:24075808). Localizes to pericentriolar material
CC       (PCM) (By similarity). {ECO:0000250|UniProtKB:O94986,
CC       ECO:0000269|PubMed:24075808}.
CC   -!- SIMILARITY: Belongs to the CEP152 family. {ECO:0000305}.
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DR   EMBL; BC100229; AAI00230.1; -; mRNA.
DR   RefSeq; NP_001087086.1; NM_001093617.1.
DR   AlphaFoldDB; Q498G2; -.
DR   SMR; Q498G2; -.
DR   GeneID; 446951; -.
DR   KEGG; xla:446951; -.
DR   CTD; 446951; -.
DR   Xenbase; XB-GENE-988613; cep152.L.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 446951; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0098536; C:deuterosome; IDA:UniProtKB.
DR   GO; GO:0000242; C:pericentriolar material; ISS:UniProtKB.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0098535; P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; IDA:UniProtKB.
DR   InterPro; IPR029598; Cep152.
DR   PANTHER; PTHR10337:SF6; PTHR10337:SF6; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..1663
FT                   /note="Centrosomal protein of 152 kDa"
FT                   /id="PRO_0000424821"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1383..1408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1595..1628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          266..516
FT                   /evidence="ECO:0000255"
FT   COILED          571..664
FT                   /evidence="ECO:0000255"
FT   COILED          696..796
FT                   /evidence="ECO:0000255"
FT   COILED          843..886
FT                   /evidence="ECO:0000255"
FT   COILED          946..977
FT                   /evidence="ECO:0000255"
FT   COILED          1014..1047
FT                   /evidence="ECO:0000255"
FT   COILED          1182..1288
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1663 AA;  192175 MW;  937FFE92D2D41CDD CRC64;
     MSIDFDSGAL QTQQEDEEYD KEDYAREQEL QQLLTDLPHD MLDDSLSSSP EPSYSDCSGH
     EISEKIPQWE HGANWGNDDL PNHQKPYKNG FTENQYCMGF VGKQDEHLRN QAGRDKMSNG
     WDVLHANEDD PMFNGKYRYS KDHAYNSESN GQAFHGGDHY DAPGHCSSSE LYHLPDDFQP
     YTNCQQVEHF PDSKKEHFQG FAVPEETSKI STEPFQVKYN PYQIKVARMD EMNQDPERRD
     GNFDDLQREF LDTGENSTGN MQFVQLQVLY KARGRQLEEQ NNKLEESERQ IRYLNHQLAI
     VKDQKDGLTI SLQESQSLLQ NSREMEIQLK GQLTALEKTV ESLTTNEEQL RKELNISKVA
     MESFQQQLLD LRRSESIQRA REQHETVVSM LKKKHEEQVL ALQQKLDDVN AMLNEEKELC
     SRLETRLKLS ERKEAESKLE KTDIINRLSK SLEESQKQCA NLLQSGSIQE ATQLRLQLQQ
     VQSSKIINDG MNKALQEEVR ELQEQITMYE SAARLGAFVN SGEEQQLSDS YVELGIKNFN
     WQKSRLGRIV ANNGVKNDLS SEEIILELKT ELERCLNSNK TKRKQIVQLQ AELKGHLLKN
     EELKKSMEIA ERTARDSQIQ AENLANKVNN SPFYSSSSDR FREEIQKLQS EKQILQQENE
     KHLLFIKEFT VNEEKLKASN QELCNEMRGM IQDFDQDKKE AIERCERTYE QHNEDIKAHL
     LNELYEKFES EKELLSQGYE EKITLLQAQM NEIHREMAAV QECYIAVCKE KDALEENMRE
     HFKKELQKSE EEVTAKAIQD VEMEWAQKLN QALQDAKTKS LQSFETQTIQ TDESSLAKSD
     LNSDCIDELK VKLQNAIQEK EKAVHQAQLE LEERHHEETS KQVEVALTRA YGRWLQELTS
     LPEYKARLKL EQEKWEKTNE RNVERQVSDA LYAAEIKWKM RSDKVDFTVR QKEFEEKIAS
     MKRELELKAE ESQALLKAEI ATSRAQWNKE KHDEIQRLRE DNEKDYRVFL DEHRNKLTDT
     LSTAKVEFEK QKNELIAQKD REMAERLDES LKQWALDESR RMRALENEIL SEVEQCMYEI
     HDQLLDKSIV KDRLPSMKSN LDVTFLEKLK ACLQKSVKGI LYKVLANARQ DWKKKYDTES
     NQETGIRGGE LEGSDDRKTA KMWYLDKDLG KTEKQPCCEH WVQQLEKSKK ECYEIRSKLE
     KACRHLQQLV KEQKLKAEKY RKNHILTEEL KKQNSELQKK LELTVAPSPA CLEPVEGGSN
     GCMMCNGNAL EEIRAQYIKA VDKIKNDMLR YIHESKGRAA ELLKSEVLRE RQETARKMRK
     YYLTCLQQLL KDDGNNEGAE KKIINAASKL ATMAKVLETP VSQKYQSKSL NSDLPQNENF
     LSETTQDQRS LQKPAHSHQN NNPLNQNIDQ QTIEELIKRH VREKSDGNKV TDAEGASAIN
     ENSSFPTLRK SLVDNGNSQF VPSAPFQKLK TFSCIDSSTE GVLVTHQNKQ SALQSGTLYP
     NSEHPKKKPG LQRFDLQETP VRDENGSNDW SCISSKSLFQ PHSAKGSLTQ LKMGPQNADV
     EEHSSAVASC SLAEENHNTF SSGARNQHFF AQVAKRKDEN SGRKYSNKIQ EPSATGIHPE
     SKLFSDVGQG NKLPSRKLLL DFTLSPQQDS GFDSPFPNLN NFN