ID   CE41A_XENLA             Reviewed;         365 AA.
AC   Q6NTY8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Centrosomal protein of 41 kDa A;
DE            Short=Cep41-A;
GN   Name=cep41-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required during ciliogenesis for tubulin glutamylation in
CC       cilium. Probably acts by participating in the transport of tubulin
CC       polyglutamylases between the basal body and the cilium (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cell projection, cilium
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes mainly to the cilium basal body and in
CC       primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP41 family. {ECO:0000305}.
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DR   EMBL; BC068814; AAH68814.1; -; mRNA.
DR   RefSeq; NP_001084660.1; NM_001091191.1.
DR   AlphaFoldDB; Q6NTY8; -.
DR   DNASU; 414620; -.
DR   GeneID; 414620; -.
DR   KEGG; xla:414620; -.
DR   CTD; 414620; -.
DR   Xenbase; XB-GENE-980653; cep41.S.
DR   OMA; EIQRLEX; -.
DR   OrthoDB; 1216222at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 414620; Expressed in internal ear and 12 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   Pfam; PF00581; Rhodanese; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..365
FT                   /note="Centrosomal protein of 41 kDa A"
FT                   /id="PRO_0000416268"
FT   DOMAIN          177..274
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   REGION          104..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41185 MW;  E2A65BF3F81E0D3B CRC64;
     MSAKRSIGDS EILKKRIPQN QKYEHIKTRL DTGNSMTKYL ERIEDIKRNY RYKKDELFKR
     IKVTTFAQLV LQVASVTEER ESGEMTTDEL QRLEDNSSVI SDTEFLTDRP NGKGSPANES
     NSPIQFIDSE RGEELIQTSR STLQSVISGV GELDLGNQAD IKKESLPSSS ALDKPYEDCP
     FLLLDVRDRD SYDQCHIVGA RNYPIAMLSR TMNPFTPEIL EYRNAHGKII ILYDEDERVA
     SQAASTMCER GFENLFMLSG GLKVISQRFP QGLTTGSFPI TCLAPPTQTK SALKRTPKDP
     IIPAENKWRF SSQDLEMIEN HLENVLMSTS TPSRLRMDSR NSKVPSSASS ARSQSSTSSH
     SKPWK