ID   CE41B_XENLA             Reviewed;         365 AA.
AC   A0JPH7;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Centrosomal protein of 41 kDa B;
DE            Short=Cep41-B;
GN   Name=cep41-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required during ciliogenesis for tubulin glutamylation in
CC       cilium. Probably acts by participating in the transport of tubulin
CC       polyglutamylases between the basal body and the cilium (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cell projection, cilium
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes mainly to the cilium basal body and in
CC       primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP41 family. {ECO:0000305}.
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DR   EMBL; BC127427; AAI27428.1; -; mRNA.
DR   RefSeq; NP_001090561.1; NM_001097092.1.
DR   AlphaFoldDB; A0JPH7; -.
DR   BioGRID; 674077; 1.
DR   IntAct; A0JPH7; 2.
DR   DNASU; 100036799; -.
DR   GeneID; 100036799; -.
DR   KEGG; xla:100036799; -.
DR   CTD; 100036799; -.
DR   Xenbase; XB-GENE-17343004; cep41.L.
DR   OrthoDB; 1216222at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100036799; Expressed in internal ear and 12 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   Pfam; PF00581; Rhodanese; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..365
FT                   /note="Centrosomal protein of 41 kDa B"
FT                   /id="PRO_0000416269"
FT   DOMAIN          177..274
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41109 MW;  8FBC30E928811E25 CRC64;
     MSAKRSIGDP EILKKRIPQN QKYQHVKTRL DTGNSMTKYM ERIEEIKKNY RYKKDELFKR
     IKVSTFAQLV LQVASVSEER ESGEMTADEL QRLEDNSSVI SDTEFLTDRP NGKGSPVSES
     KSPVQFIDSE RGEEFIQTSR STLQSVISGV GELDLGNQAD KEKQSLPSSS ALDKPYEDCP
     FLLLDVRDRD SYDQCHIVGA RNYPTAMLSR TMNPFTSEIL EYRNAHGKII ILYDEDERIA
     SQAATTMCER GFENLFMLSG GLKVISQKFP QGLTTGSFPS TCLAPPTQTK SALKRTPRDP
     IVPAENKWRF SSQDLEIIEN HVENMLMSTS TPSRLRLDSR NSKVPSSASS ARSLSSTSSH
     SKPWK