CE57L_HUMAN
ID CE57L_HUMAN Reviewed; 460 AA.
AC Q8IYX8; G5E992;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Centrosomal protein CEP57L1;
DE AltName: Full=Centrosomal protein 57kDa-like protein 1;
DE AltName: Full=Centrosomal protein of 57 kDa-related protein;
DE Short=Cep57R;
DE AltName: Full=Cep57-related protein;
GN Name=CEP57L1; Synonyms=C6orf182, CEP57R;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [5]
RP IDENTIFICATION.
RX PubMed=18294141; DOI=10.1042/bj20071501;
RA Momotani K., Khromov A.S., Miyake T., Stukenberg P.T., Somlyo A.V.;
RT "Cep57, a multidomain protein with unique microtubule and centrosomal
RT localization domains.";
RL Biochem. J. 412:265-273(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Centrosomal protein which may be required for microtubule
CC attachment to centrosomes. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IYX8; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-1104570, EBI-739580;
CC Q8IYX8; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-1104570, EBI-10171416;
CC Q8IYX8; Q53EZ4: CEP55; NbExp=4; IntAct=EBI-1104570, EBI-747776;
CC Q8IYX8; Q8IYX8: CEP57L1; NbExp=4; IntAct=EBI-1104570, EBI-1104570;
CC Q8IYX8; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-1104570, EBI-10181988;
CC Q8IYX8; Q96MT8: CEP63; NbExp=3; IntAct=EBI-1104570, EBI-741977;
CC Q8IYX8; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-1104570, EBI-739624;
CC Q8IYX8; Q92997: DVL3; NbExp=3; IntAct=EBI-1104570, EBI-739789;
CC Q8IYX8; Q08379: GOLGA2; NbExp=6; IntAct=EBI-1104570, EBI-618309;
CC Q8IYX8; Q4V328: GRIPAP1; NbExp=6; IntAct=EBI-1104570, EBI-717919;
CC Q8IYX8; A5PKX9: INADL; NbExp=3; IntAct=EBI-1104570, EBI-12035052;
CC Q8IYX8; Q9BW62: KATNAL1; NbExp=9; IntAct=EBI-1104570, EBI-743591;
CC Q8IYX8; Q15323: KRT31; NbExp=3; IntAct=EBI-1104570, EBI-948001;
CC Q8IYX8; Q6A162: KRT40; NbExp=3; IntAct=EBI-1104570, EBI-10171697;
CC Q8IYX8; P25800: LMO1; NbExp=3; IntAct=EBI-1104570, EBI-8639312;
CC Q8IYX8; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-1104570, EBI-741037;
CC Q8IYX8; P23508: MCC; NbExp=3; IntAct=EBI-1104570, EBI-307531;
CC Q8IYX8; Q99750: MDFI; NbExp=6; IntAct=EBI-1104570, EBI-724076;
CC Q8IYX8; P55081: MFAP1; NbExp=3; IntAct=EBI-1104570, EBI-1048159;
CC Q8IYX8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-1104570, EBI-10172526;
CC Q8IYX8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-1104570, EBI-742948;
CC Q8IYX8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1104570, EBI-79165;
CC Q8IYX8; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-1104570, EBI-10171633;
CC Q8IYX8; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-1104570, EBI-11320284;
CC Q8IYX8; Q92966: SNAPC3; NbExp=3; IntAct=EBI-1104570, EBI-1760638;
CC Q8IYX8; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-1104570, EBI-1105213;
CC Q8IYX8; P40222: TXLNA; NbExp=3; IntAct=EBI-1104570, EBI-359793;
CC Q8IYX8; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1104570, EBI-6116822;
CC Q8IYX8; P07947: YES1; NbExp=3; IntAct=EBI-1104570, EBI-515331;
CC Q8IYX8; Q7Z3I7: ZNF572; NbExp=4; IntAct=EBI-1104570, EBI-10172590;
CC Q8IYX8; Q8N720: ZNF655; NbExp=3; IntAct=EBI-1104570, EBI-625509;
CC Q8IYX8; PRO_0000449621 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-1104570, EBI-25492388;
CC Q8IYX8-2; P09917: ALOX5; NbExp=3; IntAct=EBI-10181988, EBI-79934;
CC Q8IYX8-2; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-10181988, EBI-541426;
CC Q8IYX8-2; Q13895: BYSL; NbExp=5; IntAct=EBI-10181988, EBI-358049;
CC Q8IYX8-2; Q9H257: CARD9; NbExp=3; IntAct=EBI-10181988, EBI-751319;
CC Q8IYX8-2; Q8NA61: CBY2; NbExp=3; IntAct=EBI-10181988, EBI-741724;
CC Q8IYX8-2; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-10181988, EBI-10171570;
CC Q8IYX8-2; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-10181988, EBI-10171416;
CC Q8IYX8-2; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-10181988, EBI-2808286;
CC Q8IYX8-2; Q01850: CDR2; NbExp=3; IntAct=EBI-10181988, EBI-1181367;
CC Q8IYX8-2; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-10181988, EBI-744115;
CC Q8IYX8-2; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-10181988, EBI-747776;
CC Q8IYX8-2; Q96MT8: CEP63; NbExp=3; IntAct=EBI-10181988, EBI-741977;
CC Q8IYX8-2; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-10181988, EBI-739624;
CC Q8IYX8-2; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-10181988, EBI-749051;
CC Q8IYX8-2; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-10181988, EBI-740680;
CC Q8IYX8-2; Q14241: ELOA; NbExp=3; IntAct=EBI-10181988, EBI-742350;
CC Q8IYX8-2; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-10181988, EBI-742102;
CC Q8IYX8-2; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10181988, EBI-719941;
CC Q8IYX8-2; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-10181988, EBI-10175124;
CC Q8IYX8-2; O95257: GADD45G; NbExp=3; IntAct=EBI-10181988, EBI-448202;
CC Q8IYX8-2; Q92805: GOLGA1; NbExp=3; IntAct=EBI-10181988, EBI-6164177;
CC Q8IYX8-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10181988, EBI-618309;
CC Q8IYX8-2; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10181988, EBI-2514791;
CC Q8IYX8-2; Q8N4P3: HDDC3; NbExp=3; IntAct=EBI-10181988, EBI-750003;
CC Q8IYX8-2; O14964: HGS; NbExp=3; IntAct=EBI-10181988, EBI-740220;
CC Q8IYX8-2; Q13422: IKZF1; NbExp=3; IntAct=EBI-10181988, EBI-745305;
CC Q8IYX8-2; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-10181988, EBI-743591;
CC Q8IYX8-2; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-10181988, EBI-2125614;
CC Q8IYX8-2; Q6P597: KLC3; NbExp=3; IntAct=EBI-10181988, EBI-1643885;
CC Q8IYX8-2; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-10181988, EBI-949319;
CC Q8IYX8-2; A1A4E9: KRT13; NbExp=3; IntAct=EBI-10181988, EBI-10171552;
CC Q8IYX8-2; P08727: KRT19; NbExp=3; IntAct=EBI-10181988, EBI-742756;
CC Q8IYX8-2; Q15323: KRT31; NbExp=3; IntAct=EBI-10181988, EBI-948001;
CC Q8IYX8-2; O76015: KRT38; NbExp=3; IntAct=EBI-10181988, EBI-1047263;
CC Q8IYX8-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10181988, EBI-10171697;
CC Q8IYX8-2; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10181988, EBI-726510;
CC Q8IYX8-2; Q8TAP4: LMO3; NbExp=3; IntAct=EBI-10181988, EBI-742259;
CC Q8IYX8-2; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-10181988, EBI-741037;
CC Q8IYX8-2; P43355: MAGEA1; NbExp=3; IntAct=EBI-10181988, EBI-740978;
CC Q8IYX8-2; Q96E03: MAGEA2B; NbExp=3; IntAct=EBI-10181988, EBI-10239285;
CC Q8IYX8-2; P50222: MEOX2; NbExp=3; IntAct=EBI-10181988, EBI-748397;
CC Q8IYX8-2; P55081: MFAP1; NbExp=3; IntAct=EBI-10181988, EBI-1048159;
CC Q8IYX8-2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10181988, EBI-10172526;
CC Q8IYX8-2; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-10181988, EBI-399246;
CC Q8IYX8-2; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10181988, EBI-742948;
CC Q8IYX8-2; P37198: NUP62; NbExp=3; IntAct=EBI-10181988, EBI-347978;
CC Q8IYX8-2; Q16512: PKN1; NbExp=3; IntAct=EBI-10181988, EBI-602382;
CC Q8IYX8-2; Q96PV4: PNMA5; NbExp=5; IntAct=EBI-10181988, EBI-10171633;
CC Q8IYX8-2; O60437: PPL; NbExp=3; IntAct=EBI-10181988, EBI-368321;
CC Q8IYX8-2; O75771: RAD51D; NbExp=3; IntAct=EBI-10181988, EBI-1055693;
CC Q8IYX8-2; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-10181988, EBI-726876;
CC Q8IYX8-2; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-10181988, EBI-1378139;
CC Q8IYX8-2; Q5SQN1: SNAP47; NbExp=3; IntAct=EBI-10181988, EBI-10244848;
CC Q8IYX8-2; Q92966: SNAPC3; NbExp=3; IntAct=EBI-10181988, EBI-1760638;
CC Q8IYX8-2; Q8N5C8: TAB3; NbExp=3; IntAct=EBI-10181988, EBI-359964;
CC Q8IYX8-2; Q12933: TRAF2; NbExp=3; IntAct=EBI-10181988, EBI-355744;
CC Q8IYX8-2; Q9UL33: TRAPPC2L; NbExp=3; IntAct=EBI-10181988, EBI-747601;
CC Q8IYX8-2; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-10181988, EBI-2130429;
CC Q8IYX8-2; Q15654: TRIP6; NbExp=3; IntAct=EBI-10181988, EBI-742327;
CC Q8IYX8-2; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-10181988, EBI-744794;
CC Q8IYX8-2; P40222: TXLNA; NbExp=3; IntAct=EBI-10181988, EBI-359793;
CC Q8IYX8-2; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-10181988, EBI-6116822;
CC Q8IYX8-2; Q9H614; NbExp=3; IntAct=EBI-10181988, EBI-10249899;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:14654843}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYX8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYX8-2; Sequence=VSP_055660, VSP_055661;
CC -!- SIMILARITY: Belongs to the translokin family. {ECO:0000305}.
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DR EMBL; AL355305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48364.1; -; Genomic_DNA.
DR EMBL; BC033448; AAH33448.1; -; mRNA.
DR CCDS; CCDS5071.1; -. [Q8IYX8-1]
DR CCDS; CCDS64491.1; -. [Q8IYX8-2]
DR RefSeq; NP_001077004.1; NM_001083535.1. [Q8IYX8-1]
DR RefSeq; NP_001258781.1; NM_001271852.1. [Q8IYX8-1]
DR RefSeq; NP_001258782.1; NM_001271853.1. [Q8IYX8-2]
DR RefSeq; NP_776191.1; NM_173830.4. [Q8IYX8-1]
DR RefSeq; XP_016866259.1; XM_017010770.1.
DR AlphaFoldDB; Q8IYX8; -.
DR SMR; Q8IYX8; -.
DR BioGRID; 130198; 92.
DR IntAct; Q8IYX8; 90.
DR MINT; Q8IYX8; -.
DR STRING; 9606.ENSP00000427844; -.
DR iPTMnet; Q8IYX8; -.
DR PhosphoSitePlus; Q8IYX8; -.
DR BioMuta; CEP57L1; -.
DR EPD; Q8IYX8; -.
DR jPOST; Q8IYX8; -.
DR MassIVE; Q8IYX8; -.
DR MaxQB; Q8IYX8; -.
DR PaxDb; Q8IYX8; -.
DR PeptideAtlas; Q8IYX8; -.
DR PRIDE; Q8IYX8; -.
DR ProteomicsDB; 33869; -.
DR ProteomicsDB; 71260; -. [Q8IYX8-1]
DR Antibodypedia; 46535; 113 antibodies from 22 providers.
DR DNASU; 285753; -.
DR Ensembl; ENST00000359793.7; ENSP00000352841.3; ENSG00000183137.15. [Q8IYX8-1]
DR Ensembl; ENST00000368968.6; ENSP00000357964.2; ENSG00000183137.15. [Q8IYX8-2]
DR Ensembl; ENST00000517392.6; ENSP00000427844.1; ENSG00000183137.15. [Q8IYX8-1]
DR GeneID; 285753; -.
DR KEGG; hsa:285753; -.
DR MANE-Select; ENST00000517392.6; ENSP00000427844.1; NM_001271852.3; NP_001258781.1.
DR UCSC; uc003psx.5; human. [Q8IYX8-1]
DR CTD; 285753; -.
DR DisGeNET; 285753; -.
DR GeneCards; CEP57L1; -.
DR HGNC; HGNC:21561; CEP57L1.
DR HPA; ENSG00000183137; Low tissue specificity.
DR neXtProt; NX_Q8IYX8; -.
DR OpenTargets; ENSG00000183137; -.
DR PharmGKB; PA134980921; -.
DR VEuPathDB; HostDB:ENSG00000183137; -.
DR eggNOG; ENOG502QTVF; Eukaryota.
DR GeneTree; ENSGT00530000063695; -.
DR InParanoid; Q8IYX8; -.
DR OrthoDB; 1255254at2759; -.
DR PhylomeDB; Q8IYX8; -.
DR TreeFam; TF329178; -.
DR PathwayCommons; Q8IYX8; -.
DR SignaLink; Q8IYX8; -.
DR BioGRID-ORCS; 285753; 15 hits in 1071 CRISPR screens.
DR ChiTaRS; CEP57L1; human.
DR GenomeRNAi; 285753; -.
DR Pharos; Q8IYX8; Tdark.
DR PRO; PR:Q8IYX8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IYX8; protein.
DR Bgee; ENSG00000183137; Expressed in buccal mucosa cell and 105 other tissues.
DR ExpressionAtlas; Q8IYX8; baseline and differential.
DR Genevisible; Q8IYX8; HS.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..460
FT /note="Centrosomal protein CEP57L1"
FT /id="PRO_0000189534"
FT REGION 399..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..228
FT /evidence="ECO:0000255"
FT COILED 317..384
FT /evidence="ECO:0000255"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 389..391
FT /note="CKL -> RRL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055660"
FT VAR_SEQ 392..460
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055661"
FT VARIANT 194
FT /note="D -> E (in dbSNP:rs351733)"
FT /id="VAR_052396"
SQ SEQUENCE 460 AA; 53649 MW; 60BFD7F54078A9F5 CRC64;
MDSELMHSIV GSYHKPPERV FVPSFTQNEP SQNCHPANLE VTSPKILHSP NSQALILALK
TLQEKIHRLE LERTQAEDNL NILSREAAQY KKALENETNE RNLAHQELIK QKKDISIQLS
SAQSRCTLLE KQLEYTKRMV LNVEREKNMI LEQQAQLQRE KEQDQMKLYA KLEKLDVLEK
ECFRLTTTQK TAEDKIKHLE EKLKEEEHQR KLFQDKASEL QTGLEISKII MSSVSNLKHS
KEKKKSSKKT KCIKRRPPWQ ICSKFGALPF VAEKMRQHRD PHILQKPFNV TETRCLPKPS
RTTSWCKAIP PDSEKSISIC DNLSELLMAM QDELDQMSME HQELLKQMKE TESHSVCDDI
ECELECLLKK MEIKGEQISK LKKHQDSVCK LQQKVQNSKM SEASGIQQED SYPKGSKNIK
NSPRKCLTDT NLFQKNSSFH PIRVHNLQMK LRRDDIMWEQ
