ID   CE57L_RAT               Reviewed;         430 AA.
AC   Q6AXZ4;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Centrosomal protein CEP57L1;
DE   AltName: Full=Centrosomal protein 57kDa-like protein 1;
DE   AltName: Full=Centrosomal protein of 57 kDa-related protein;
DE            Short=Cep57R;
DE   AltName: Full=Cep57-related protein;
GN   Name=Cep57l1; Synonyms=Cep57r;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Centrosomal protein which may be required for microtubule
CC       attachment to centrosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the translokin family. {ECO:0000305}.
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DR   EMBL; BC079256; AAH79256.1; -; mRNA.
DR   RefSeq; XP_006256627.1; XM_006256565.2.
DR   RefSeq; XP_006256628.1; XM_006256566.3.
DR   RefSeq; XP_006256629.1; XM_006256567.3.
DR   AlphaFoldDB; Q6AXZ4; -.
DR   SMR; Q6AXZ4; -.
DR   STRING; 10116.ENSRNOP00000000331; -.
DR   PhosphoSitePlus; Q6AXZ4; -.
DR   PaxDb; Q6AXZ4; -.
DR   Ensembl; ENSRNOT00000000331; ENSRNOP00000000331; ENSRNOG00000000303.
DR   GeneID; 294519; -.
DR   CTD; 285753; -.
DR   RGD; 1311358; Cep57l1.
DR   eggNOG; ENOG502QTVF; Eukaryota.
DR   GeneTree; ENSGT00530000063695; -.
DR   HOGENOM; CLU_034321_0_0_1; -.
DR   InParanoid; Q6AXZ4; -.
DR   OrthoDB; 1255254at2759; -.
DR   PhylomeDB; Q6AXZ4; -.
DR   TreeFam; TF329178; -.
DR   PRO; PR:Q6AXZ4; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Genevisible; Q6AXZ4; RN.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   InterPro; IPR025913; Cep57_CLD.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   Pfam; PF14073; Cep57_CLD; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..430
FT                   /note="Centrosomal protein CEP57L1"
FT                   /id="PRO_0000189536"
FT   REGION          248..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          46..213
FT                   /evidence="ECO:0000255"
FT   COILED          290..377
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        248..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IYX8"
SQ   SEQUENCE   430 AA;  50274 MW;  E8465CE346F54EC4 CRC64;
     MDAELPHSMI GSYLNPPERM YLPSFSQTEA SQNCHPGSSP KMFNSPNNQA LVSALKTLQE
     KIRRLELERT QAEDNLNLLS REAAQYKKAL EEETNERNLA HEELTRQKKD ISIQLSSAQS
     RCILLEKQLE YTKRMVLNVE REKNMILEQQ AQLQREKEQD QMKLHAKLEK LDVLEKECLR
     LTTTQQTAEE KIKYLEEKLK EEEHQRRLFQ DRACELQTGL EISKILMSTV SSSKLCNERK
     KLPKKTNCLK REPPQHTDCR FRGPASERER PPFRMTSSAR AEPHSSGEPF SICDNLSELL
     RTMQDELDQM NMEHRELLRQ IAQTGSHSDS EELEQELEHL ARKMESKEDQ ISKLQKHQDR
     VRKLQEKVEN SRINESSGIH GNPKRSKNLK TSPRKCLSET SAFQKDRSFQ PVKVHSLPPR
     LRRDDVKWEQ