ID   CE57L_XENLA             Reviewed;         488 AA.
AC   Q5FWP9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Centrosomal protein cep57l1;
DE   AltName: Full=Centrosomal protein 57kDa-like protein 1;
DE   AltName: Full=Centrosomal protein of 57 kDa;
DE            Short=Cep57;
DE            Short=XCep57;
DE   AltName: Full=Cep57-related protein;
DE            Short=Cep57R;
GN   Name=cep57l1; Synonyms=cep57, cep57r;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CLIP1; GAMMA-TUBULIN;
RP   MIS12; NDC80 AND ZWINT.
RX   PubMed=17803911; DOI=10.1016/j.cell.2007.07.023;
RA   Emanuele M.J., Stukenberg P.T.;
RT   "Xenopus Cep57 is a novel kinetochore component involved in microtubule
RT   attachment.";
RL   Cell 130:893-905(2007).
CC   -!- FUNCTION: Required for spindle microtubule attachment to both
CC       kinetochores and centrosomes. Also functions to tether minus-ends of
CC       spindle microtubules to centrosomes. May act by forming ring-like
CC       structures around microtubules, or by serving as a cross-linker or
CC       scaffold at the attachment site. {ECO:0000269|PubMed:17803911}.
CC   -!- SUBUNIT: Interacts with clip1, mis12, ndc80 and zwint. Interacts with
CC       gamma-tubulin. {ECO:0000269|PubMed:17803911}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:17803911}. Chromosome,
CC       centromere, kinetochore {ECO:0000269|PubMed:17803911}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000269|PubMed:17803911}. Note=Localizes to
CC       spindle microtubules.
CC   -!- SIMILARITY: Belongs to the translokin family. {ECO:0000305}.
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DR   EMBL; BC089255; AAH89255.1; -; mRNA.
DR   RefSeq; NP_001089236.1; NM_001095767.1.
DR   AlphaFoldDB; Q5FWP9; -.
DR   SMR; Q5FWP9; -.
DR   PRIDE; Q5FWP9; -.
DR   DNASU; 734283; -.
DR   GeneID; 734283; -.
DR   KEGG; xla:734283; -.
DR   CTD; 734283; -.
DR   Xenbase; XB-GENE-5897421; cep57l1.L.
DR   OrthoDB; 1255254at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 734283; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR   GO; GO:0005876; C:spindle microtubule; IDA:UniProtKB.
DR   GO; GO:0043015; F:gamma-tubulin binding; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IMP:UniProtKB.
DR   InterPro; IPR025913; Cep57_CLD.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   Pfam; PF14073; Cep57_CLD; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore;
KW   Microtubule; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Centrosomal protein cep57l1"
FT                   /id="PRO_0000381818"
FT   REGION          232..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          71..226
FT                   /evidence="ECO:0000255"
FT   COILED          377..403
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        425..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55108 MW;  351075E06862955B CRC64;
     MESVSKESYL PSFHQFPLCA SLSEFESASS KETQSSALKN ISPHPYDILQ APNSRALISA
     LKTLQNKICR LESEKTHARD RLTNLSRAAG EHKKVLESEK RSAEWAAQEA TSQKNDVAMQ
     LNNAEQRCSL LEKQLDYMRK MMENADIQNN PIHQIPAQKE QKDMLEMQSK LQKLEVLENE
     CLRLKATHKS SENKIQFLEE KLSVEEQERK ALQDKAAQVQ TSLEVNRILL SSASSQNSTQ
     RKVKKKKQSK QKNAISKEPS SKEPLSKEPP SKCFFPKAGE LPFVAGKSTT SSHSLSANVQ
     NMLHMMKHQS PRVSQKDPKT VEHKPSILPG GSRSIPTRLM SSSTGDTLSD ILLALQDELG
     QMSFEHQELL KHIDETKNTD MREDLERELD YLVKQMEIKS DQIIKLKRHQ LNVAKLKKTA
     KKQPRPPSTT KPAEDEQNIG ATDPCTPRNK GNLANGTGTP NSKASLELLK SVRKIQMTLK
     KDDIMWEK