ID   CE57L_XENTR             Reviewed;         483 AA.
AC   Q28BZ7; A9ULF2; Q0VFM8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Centrosomal protein cep57l1;
DE   AltName: Full=Centrosomal protein 57kDa-like protein 1;
DE   AltName: Full=Centrosomal protein of 57 kDa;
DE            Short=Cep57;
DE   AltName: Full=Cep57-related protein;
DE            Short=Cep57R;
GN   Name=cep57l1; Synonyms=cep57, cep57r; ORFNames=TEgg135a06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-397 (ISOFORM 1), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 1-399 (ISOFORM 2).
RC   STRAIN=N6; TISSUE=Liver, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for spindle microtubule attachment to both
CC       kinetochores and centrosomes. Also functions to tether minus-ends of
CC       spindle microtubules to centrosomes. May act by forming ring-like
CC       structures around microtubules, or by serving as a cross-linker or
CC       scaffold at the attachment site (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with clip1, mis12, ndc80 and zwint. Interacts with
CC       gamma-tubulin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC       Note=Localizes to spindle microtubules. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28BZ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28BZ7-2; Sequence=VSP_037848;
CC   -!- SIMILARITY: Belongs to the translokin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI18771.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=AAI57234.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; CR942538; CAJ82055.1; -; mRNA.
DR   EMBL; BC118770; AAI18771.1; ALT_SEQ; mRNA.
DR   EMBL; BC157233; AAI57234.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001039145.1; NM_001045680.1. [Q28BZ7-1]
DR   AlphaFoldDB; Q28BZ7; -.
DR   SMR; Q28BZ7; -.
DR   STRING; 8364.ENSXETP00000012868; -.
DR   PaxDb; Q28BZ7; -.
DR   PRIDE; Q28BZ7; -.
DR   GeneID; 733970; -.
DR   KEGG; xtr:733970; -.
DR   CTD; 285753; -.
DR   Xenbase; XB-GENE-5897356; cep57l1.
DR   eggNOG; ENOG502QTVF; Eukaryota.
DR   InParanoid; Q28BZ7; -.
DR   OrthoDB; 1255254at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   InterPro; IPR025913; Cep57_CLD.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   Pfam; PF14073; Cep57_CLD; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Centromere; Chromosome; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Kinetochore; Microtubule; Reference proteome.
FT   CHAIN           1..483
FT                   /note="Centrosomal protein cep57l1"
FT                   /id="PRO_0000381819"
FT   REGION          237..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          94..228
FT                   /evidence="ECO:0000255"
FT   COILED          375..418
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         160..194
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_037848"
SQ   SEQUENCE   483 AA;  54747 MW;  F6FBDF76FE27699B CRC64;
     MESLSKESYL SSFHQFPSYA PLPDHIKFES VSSKKIQCSA LENISPHQYD ILQAPNSRAL
     ISALKTLQEK ICRLELEKTH ARDRLTNLTR VAGEHKKVLE SEKQSAELAA KEATNQQNDI
     GKQLNNAKQR CSLLEKQLDY MKEMMENADT QKTTIHEHQM LTQKEQKEIQ SKLKKLEVLE
     KMCTRLSATH KSAETKIQHL EEKLSVEEQN RKALQDKAAQ VQTSLEVNRI LLSSASAQNS
     TQRKVKKKKQ SKLKNSVSKE PPSKCFYPKA GELPFVAGKS TTSSHSLSAN VQNVLHMMKH
     HSPQVSQKNP KTAEHKPSVL PGGSRTIPTR LISSFTGDNL SDILLALQDE LGQMSFEHQE
     LLRHINETKN TDMREDLERE LDYVVKQMEI KSDQIMKLKR HQLNVNKLKK TAKLLKEQPR
     PTSVTKLAAD KQNTGAKDPS TPRRKGDLAD GSGTPNSKAS LELLKSVRKI QMTLKKDDIM
     WEK