ID   CE63B_XENLA             Reviewed;         648 AA.
AC   Q5HZK9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Centrosomal protein of 63 kDa-B;
DE            Short=Cep63-B;
GN   Name=cep63-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal spindle assembly. Plays a key role in
CC       mother-centriole-dependent centriole duplication. Plays a role in DNA
CC       damage response: following DNA double strand breaks (DSBs), it is
CC       delocalized from centrosomes due to phosphorylation by atm and atr,
CC       leading to inactivate spindle assembly and delay mitotic progression
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000250}.
CC   -!- PTM: Phosphorylation at Ser-559 by atm and atr promotes its
CC       delocalization from the centrosome and impairs its ability to promote
CC       centrosome dependent spindle assembly. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP63 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88974.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC088974; AAH88974.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; Q5HZK9; -.
DR   SMR; Q5HZK9; -.
DR   PRIDE; Q5HZK9; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0042770; P:signal transduction in response to DNA damage; ISS:UniProtKB.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR029608; Cep63.
DR   InterPro; IPR031470; Cep63/Deup1_N.
DR   PANTHER; PTHR18875:SF7; PTHR18875:SF7; 1.
DR   Pfam; PF17045; CEP63; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   DNA damage; Mitosis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..648
FT                   /note="Centrosomal protein of 63 kDa-B"
FT                   /id="PRO_0000381810"
FT   COILED          19..188
FT                   /evidence="ECO:0000255"
FT   COILED          222..555
FT                   /evidence="ECO:0000255"
FT   COILED          611..644
FT                   /evidence="ECO:0000255"
FT   MOD_RES         559
FT                   /note="Phosphoserine; by atm and atr"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   648 AA;  75239 MW;  7FD088ECE9D91574 CRC64;
     MEALLQGLQR QDRMGALQDS CEAELQELMK QIDIMLDHKR SQWEAETETM KTRLELKEQE
     LNCALDSEER LNQEVRRLRQ QLIQQEEETQ NKTTQYEAQL SGFKEELNRL KKSYEKVQKK
     HLRSEMKAKA EEERSEVSRL TRRLEEFRQR SLDWEKQRLL YQQQLSGLEA QRKTLIEQTE
     MYQQQSHNRK QMLEQTNLVG RSELQNLSGQ LHRANDSLCA KEEELETLKI QLRCAVEGQK
     RAEHETELSK QAVQALKEKA ELRATLQAHT EFLQGSRVQK HELLPEGYRG SEVLRENNSI
     RSLEERLQET GQVGGETEVE AIRSKLSVSR MNEQRLQAEV TCLEDSVESV TSQCQLLAKE
     LKGKEEYLHG VKEDHQKCLS ENKKLKGQLS QAELTHKSVL DGMRKEISQL TQELHQRDIR
     MASSAGIDWE RKIKAERQRA EREAAEHRMS LNALENLRQE NCRLSELLQT QEPDVAQALV
     NLEQANQRLQ RELLQTQEKL ELIAQRRESE IQNAVDSISQ ELLNKQEQEL RIMQERLKVY
     EQEMQTFRSQ QDAASSGSSL ESIFSEVWKE QATGSPISAA SVDSAIEPVE DLASSLPVPP
     TSPANAVASR FLQEEEQRSH ELLQRLNAHI EELKQESQRT VEHFTQAR