CE85L_HUMAN
ID CE85L_HUMAN Reviewed; 805 AA.
AC Q5SZL2; A1A4E1; A2A3P2; A2IDE5; F8W6J2; G3V0H3; Q2TAM2; Q5T323; Q7Z5K7;
AC Q9H289;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Centrosomal protein of 85 kDa-like {ECO:0000305};
DE AltName: Full=Serologically defined breast cancer antigen NY-BR-15;
GN Name=CEP85L {ECO:0000312|HGNC:HGNC:21638}; Synonyms=C6orf204;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT THR-251.
RC TISSUE=Testis;
RA Sha J.H., Zhou Z.M., Li J.M.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLY-137
RP AND THR-251.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-674 (ISOFORM 4), TISSUE SPECIFICITY,
RP CHROMOSOMAL TRANSLOCATION WITH PDGFRB, AND POSSIBLE INVOLVEMENT IN
RP T-LYMPHOBLASTIC LYMPHOMA.
RC TISSUE=Peripheral blood;
RX PubMed=21938754; DOI=10.1002/gcc.20930;
RA Chmielecki J., Peifer M., Viale A., Hutchinson K., Giltnane J., Socci N.D.,
RA Hollis C.J., Dean R.S., Yenamandra A., Jagasia M., Kim A.S., Dave U.P.,
RA Thomas R.K., Pao W.;
RT "Systematic screen for tyrosine kinase rearrangements identifies a novel
RT C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated
RT myeloproliferative neoplasm.";
RL Genes Chromosomes Cancer 51:54-65(2012).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 260-805 (ISOFORM 1).
RC TISSUE=Mammary tumor;
RX PubMed=12747765;
RA Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O.,
RA Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.;
RT "Humoral immunity to human breast cancer: antigen definition and
RT quantitative analysis of mRNA expression.";
RL Cancer Immun. 1:4-4(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=21399614; DOI=10.1038/emboj.2011.63;
RA Jakobsen L., Vanselow K., Skogs M., Toyoda Y., Lundberg E., Poser I.,
RA Falkenby L.G., Bennetzen M., Westendorf J., Nigg E.A., Uhlen M.,
RA Hyman A.A., Andersen J.S.;
RT "Novel asymmetrically localizing components of human centrosomes identified
RT by complementary proteomics methods.";
RL EMBO J. 30:1520-1535(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-207, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP VARIANT [LARGE SCALE ANALYSIS] PHE-345.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [11]
RP INVOLVEMENT IN LIS10, VARIANTS LIS10 CYS-58; ASN-65; THR-68 AND ARG-69,
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=32097630; DOI=10.1016/j.neuron.2020.01.027;
RG University of Washington Center for Mendelian Genomics;
RA Tsai M.H., Muir A.M., Wang W.J., Kang Y.N., Yang K.C., Chao N.H., Wu M.F.,
RA Chang Y.C., Porter B.E., Jansen L.A., Sebire G., Deconinck N., Fan W.L.,
RA Su S.C., Chung W.H., Almanza Fuerte E.P., Mehaffey M.G., Ng C.C.,
RA Chan C.K., Lim K.S., Leventer R.J., Lockhart P.J., Riney K., Damiano J.A.,
RA Hildebrand M.S., Mirzaa G.M., Dobyns W.B., Berkovic S.F., Scheffer I.E.,
RA Tsai J.W., Mefford H.C.;
RT "Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior
RT Predominant Lissencephaly.";
RL Neuron 106:237.e1-245.e8(2020).
CC -!- FUNCTION: Plays an essential role in neuronal cell migration.
CC {ECO:0000269|PubMed:32097630}.
CC -!- INTERACTION:
CC Q5SZL2-5; O00233: PSMD9; NbExp=3; IntAct=EBI-12344751, EBI-750973;
CC Q5SZL2-5; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-12344751, EBI-11523345;
CC Q5SZL2-5; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-12344751, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:14654843,
CC ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:32097630}.
CC Note=Localized specifically to the pericentriolar region.
CC {ECO:0000269|PubMed:32097630}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q5SZL2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SZL2-2; Sequence=VSP_027338, VSP_027339, VSP_027340;
CC Name=3;
CC IsoId=Q5SZL2-3; Sequence=VSP_027337, VSP_027339, VSP_027340;
CC Name=4;
CC IsoId=Q5SZL2-4; Sequence=VSP_027338;
CC Name=5;
CC IsoId=Q5SZL2-5; Sequence=VSP_027339, VSP_027340;
CC -!- TISSUE SPECIFICITY: Isoform 1 and isoform 4 are expressed in spleen,
CC lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1
CC expressed at higher levels. Isoform 4 is detected in K-562 leukemia
CC cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL)
CC patients. {ECO:0000269|PubMed:21938754}.
CC -!- DISEASE: Note=A chromosomal aberration involving CEP85L is found in a
CC patient with T-lymphoblastic lymphoma (T-ALL) and an associated
CC myeloproliferative neoplasm (MPN) with eosinophilia. Translocation
CC t(5;6)(q33-34;q23) with PDGFRB. The translocation fuses the 5'-end of
CC CEP85L (isoform 4) to the 3'-end of PDGFRB.
CC {ECO:0000269|PubMed:21938754}.
CC -!- DISEASE: Lissencephaly 10 (LIS10) [MIM:618873]: A form of
CC lissencephaly, a disorder of cortical development characterized by
CC agyria or pachygyria and disorganization of the clear neuronal
CC lamination of normal six-layered cortex. LIS10 is an autosomal dominant
CC form clinically characterized by variably delayed development, mildly
CC to moderately impaired intellectual development, language delay, and
CC seizures. Some patients have normal early development and borderline to
CC mild cognitive impairment. {ECO:0000269|PubMed:32097630}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the CEP85 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI10836.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY313778; AAP81009.1; -; mRNA.
DR EMBL; AL359634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z99496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48196.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48197.1; -; Genomic_DNA.
DR EMBL; BC110835; AAI10836.1; ALT_INIT; mRNA.
DR EMBL; BC126140; AAI26141.1; -; mRNA.
DR EMBL; BC126142; AAI26143.1; -; mRNA.
DR EMBL; AF308284; AAG48252.1; -; mRNA.
DR CCDS; CCDS43498.1; -. [Q5SZL2-1]
DR CCDS; CCDS5119.2; -. [Q5SZL2-5]
DR CCDS; CCDS55052.1; -. [Q5SZL2-4]
DR RefSeq; NP_001035940.1; NM_001042475.2. [Q5SZL2-1]
DR RefSeq; NP_001171506.1; NM_001178035.1. [Q5SZL2-4]
DR RefSeq; NP_996804.2; NM_206921.2. [Q5SZL2-5]
DR RefSeq; XP_011534111.1; XM_011535809.2. [Q5SZL2-1]
DR RefSeq; XP_016866335.1; XM_017010846.1. [Q5SZL2-4]
DR AlphaFoldDB; Q5SZL2; -.
DR SMR; Q5SZL2; -.
DR BioGRID; 132255; 27.
DR IntAct; Q5SZL2; 15.
DR STRING; 9606.ENSP00000357474; -.
DR iPTMnet; Q5SZL2; -.
DR PhosphoSitePlus; Q5SZL2; -.
DR BioMuta; CEP85L; -.
DR DMDM; 74762226; -.
DR EPD; Q5SZL2; -.
DR jPOST; Q5SZL2; -.
DR MassIVE; Q5SZL2; -.
DR MaxQB; Q5SZL2; -.
DR PaxDb; Q5SZL2; -.
DR PeptideAtlas; Q5SZL2; -.
DR PRIDE; Q5SZL2; -.
DR ProteomicsDB; 64080; -. [Q5SZL2-1]
DR ProteomicsDB; 64081; -. [Q5SZL2-2]
DR ProteomicsDB; 64082; -. [Q5SZL2-3]
DR ProteomicsDB; 64083; -. [Q5SZL2-4]
DR ProteomicsDB; 64084; -. [Q5SZL2-5]
DR Antibodypedia; 32566; 79 antibodies from 15 providers.
DR DNASU; 387119; -.
DR Ensembl; ENST00000360290.7; ENSP00000353434.3; ENSG00000111860.14. [Q5SZL2-3]
DR Ensembl; ENST00000368488.9; ENSP00000357474.5; ENSG00000111860.14. [Q5SZL2-4]
DR Ensembl; ENST00000368491.8; ENSP00000357477.3; ENSG00000111860.14. [Q5SZL2-1]
DR Ensembl; ENST00000392500.7; ENSP00000376288.3; ENSG00000111860.14. [Q5SZL2-2]
DR Ensembl; ENST00000419517.2; ENSP00000393317.2; ENSG00000111860.14. [Q5SZL2-5]
DR GeneID; 387119; -.
DR KEGG; hsa:387119; -.
DR MANE-Select; ENST00000368491.8; ENSP00000357477.3; NM_001042475.3; NP_001035940.1.
DR UCSC; uc003pxz.3; human. [Q5SZL2-1]
DR CTD; 387119; -.
DR DisGeNET; 387119; -.
DR GeneCards; CEP85L; -.
DR HGNC; HGNC:21638; CEP85L.
DR HPA; ENSG00000111860; Tissue enhanced (testis).
DR MalaCards; CEP85L; -.
DR MIM; 618865; gene.
DR MIM; 618873; phenotype.
DR neXtProt; NX_Q5SZL2; -.
DR OpenTargets; ENSG00000111860; -.
DR PharmGKB; PA134984681; -.
DR VEuPathDB; HostDB:ENSG00000111860; -.
DR eggNOG; ENOG502QR5U; Eukaryota.
DR GeneTree; ENSGT00620000087993; -.
DR HOGENOM; CLU_020103_1_0_1; -.
DR InParanoid; Q5SZL2; -.
DR OMA; SALDCKY; -.
DR OrthoDB; 489645at2759; -.
DR PhylomeDB; Q5SZL2; -.
DR TreeFam; TF331041; -.
DR PathwayCommons; Q5SZL2; -.
DR SignaLink; Q5SZL2; -.
DR BioGRID-ORCS; 387119; 12 hits in 1074 CRISPR screens.
DR ChiTaRS; CEP85L; human.
DR GenomeRNAi; 387119; -.
DR Pharos; Q5SZL2; Tbio.
DR PRO; PR:Q5SZL2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5SZL2; protein.
DR Bgee; ENSG00000111860; Expressed in thymus and 195 other tissues.
DR ExpressionAtlas; Q5SZL2; baseline and differential.
DR Genevisible; Q5SZL2; HS.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; IDA:UniProtKB.
DR GO; GO:0001764; P:neuron migration; IMP:UniProtKB.
DR InterPro; IPR040210; Cep85/Cep85L.
DR InterPro; IPR029778; CEP85L.
DR PANTHER; PTHR31075; PTHR31075; 1.
DR PANTHER; PTHR31075:SF2; PTHR31075:SF2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; Coiled coil; Cytoplasm;
KW Cytoskeleton; Disease variant; Lissencephaly; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..805
FT /note="Centrosomal protein of 85 kDa-like"
FT /id="PRO_0000297676"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..682
FT /evidence="ECO:0000255"
FT COMPBIAS 63..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 674..675
FT /note="Breakpoint for translocation to form the CEP85L-
FT PDGFRB fusion protein"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_027337"
FT VAR_SEQ 1..24
FT /note="MWGRFLAPEASGRDSPGGARSFPA -> MIWRNNWKSTTGRLNVKLQSDKLQ
FT HGC (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:21938754"
FT /id="VSP_027338"
FT VAR_SEQ 480..496
FT /note="LKTRDRYISSLKKKCQK -> VGFSNKVELGQQHFLSI (in isoform
FT 2, isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_027339"
FT VAR_SEQ 497..805
FT /note="Missing (in isoform 2, isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_027340"
FT VARIANT 58
FT /note="S -> C (in LIS10)"
FT /evidence="ECO:0000269|PubMed:32097630"
FT /id="VAR_084269"
FT VARIANT 65
FT /note="D -> N (in LIS10)"
FT /evidence="ECO:0000269|PubMed:32097630"
FT /id="VAR_084270"
FT VARIANT 68
FT /note="I -> T (in LIS10; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32097630"
FT /id="VAR_084271"
FT VARIANT 69
FT /note="G -> R (in LIS10; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32097630"
FT /id="VAR_084272"
FT VARIANT 137
FT /note="S -> G (in dbSNP:rs3734381)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034670"
FT VARIANT 166
FT /note="D -> V (in dbSNP:rs9489444)"
FT /id="VAR_034671"
FT VARIANT 251
FT /note="P -> T (in dbSNP:rs3734382)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_034672"
FT VARIANT 345
FT /note="S -> F (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036247"
FT VARIANT 532
FT /note="Q -> H (in dbSNP:rs9489410)"
FT /id="VAR_053941"
FT VARIANT 640
FT /note="M -> V (in dbSNP:rs7743702)"
FT /id="VAR_053942"
SQ SEQUENCE 805 AA; 91808 MW; 9BFC71F0DD13A9CF CRC64;
MWGRFLAPEA SGRDSPGGAR SFPAGPDYSS AWLPANESLW QATTVPSNHR NNHIRRHSIA
SDSGDTGIGT SCSDSVEDHS TSSGTLSFKP SQSLITLPTA HVMPSNSSAS ISKLRESLTP
DGSKWSTSLM QTLGNHSRGE QDSSLDMKDF RPLRKWSSLS KLTAPDNCGQ GGTVCREESR
NGLEKIGKAK ALTSQLRTIG PSCLHDSMEM LRLEDKEINK KRSSTLDCKY KFESCSKEDF
RASSSTLRRQ PVDMTYSALP ESKPIMTSSE AFEPPKYLML GQQAVGGVPI QPSVRTQMWL
TEQLRTNPLE GRNTEDSYSL APWQQQQIED FRQGSETPMQ VLTGSSRQSY SPGYQDFSKW
ESMLKIKEGL LRQKEIVIDR QKQQITHLHE RIRDNELRAQ HAMLGHYVNC EDSYVASLQP
QYENTSLQTP FSEESVSHSQ QGEFEQKLAS TEKEVLQLNE FLKQRLSLFS EEKKKLEEKL
KTRDRYISSL KKKCQKESEQ NKEKQRRIET LEKYLADLPT LDDVQSQSLQ LQILEEKNKN
LQEALIDTEK KLEEIKKQCQ DKETQLICQK KKEKELVTTV QSLQQKVERC LEDGIRLPML
DAKQLQNEND NLRQQNETAS KIIDSQQDEI DRMILEIQSM QGKLSKEKLT TQKMMEELEK
KERNVQRLTK ALLENQRQTD ETCSLLDQGQ EPDQSRQQTV LSKRPLFDLT VIDQLFKEMS
CCLFDLKALC SILNQRAQGK EPNLSLLLGI RSMNCSAEET ENDHSTETLT KKLSDVCQLR
RDIDELRTTI SDRYAQDMGD NCITQ
