CE85L_MOUSE
ID CE85L_MOUSE Reviewed; 806 AA.
AC A0A1W2P884;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2017, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Centrosomal protein of 85 kDa-like {ECO:0000305};
GN Name=Cep85l {ECO:0000312|MGI:MGI:3642684};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=32097630; DOI=10.1016/j.neuron.2020.01.027;
RG University of Washington Center for Mendelian Genomics;
RA Tsai M.H., Muir A.M., Wang W.J., Kang Y.N., Yang K.C., Chao N.H., Wu M.F.,
RA Chang Y.C., Porter B.E., Jansen L.A., Sebire G., Deconinck N., Fan W.L.,
RA Su S.C., Chung W.H., Almanza Fuerte E.P., Mehaffey M.G., Ng C.C.,
RA Chan C.K., Lim K.S., Leventer R.J., Lockhart P.J., Riney K., Damiano J.A.,
RA Hildebrand M.S., Mirzaa G.M., Dobyns W.B., Berkovic S.F., Scheffer I.E.,
RA Tsai J.W., Mefford H.C.;
RT "Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior
RT Predominant Lissencephaly.";
RL Neuron 106:237.e1-245.e8(2020).
CC -!- FUNCTION: Plays an essential role in neuronal cell migration.
CC {ECO:0000269|PubMed:32097630}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q5SZL2}. Note=Localized
CC specifically to the pericentriolar region.
CC {ECO:0000250|UniProtKB:Q5SZL2}.
CC -!- DISRUPTION PHENOTYPE: Knockdown of the expression into neural stem
CC cells of the mouse neocortex causes a neuronal migration defect.
CC {ECO:0000269|PubMed:32097630}.
CC -!- SIMILARITY: Belongs to the CEP85 family. {ECO:0000305}.
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DR EMBL; AC105169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC153524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56701.1; -.
DR RefSeq; NP_001191912.1; NM_001204983.1.
DR AlphaFoldDB; A0A1W2P884; -.
DR SMR; A0A1W2P884; -.
DR STRING; 10090.ENSMUSP00000093356; -.
DR PhosphoSitePlus; A0A1W2P884; -.
DR ProteomicsDB; 339043; -.
DR Antibodypedia; 32566; 79 antibodies from 15 providers.
DR Ensembl; ENSMUST00000220443; ENSMUSP00000151909; ENSMUSG00000038594.
DR GeneID; 100038725; -.
DR KEGG; mmu:100038725; -.
DR CTD; 387119; -.
DR MGI; MGI:3642684; Cep85l.
DR VEuPathDB; HostDB:ENSMUSG00000038594; -.
DR eggNOG; ENOG502QR5U; Eukaryota.
DR GeneTree; ENSGT00620000087993; -.
DR OMA; SALDCKY; -.
DR OrthoDB; 489645at2759; -.
DR ChiTaRS; Cep85l; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; A0A1W2P884; protein.
DR Bgee; ENSMUSG00000038594; Expressed in spermatid and 223 other tissues.
DR ExpressionAtlas; A0A1W2P884; baseline and differential.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; ISO:MGI.
DR GO; GO:0001764; P:neuron migration; ISO:MGI.
DR InterPro; IPR040210; Cep85/Cep85L.
DR InterPro; IPR029778; CEP85L.
DR PANTHER; PTHR31075; PTHR31075; 1.
DR PANTHER; PTHR31075:SF2; PTHR31075:SF2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..806
FT /note="Centrosomal protein of 85 kDa-like"
FT /id="PRO_0000452321"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 442..644
FT /evidence="ECO:0000255"
FT COMPBIAS 61..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SZL2"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SZL2"
SQ SEQUENCE 806 AA; 91831 MW; 8009DD38A1B82D37 CRC64;
MWGRFLAPEA GGRDSPSGAR SFPAGSDYSS AWLPGNESLW QATAVPSNHR NNHLRRHSIT
SDSGDTGIGT SCSDSVEDHS TSSGTLSFKP SRSLVTLPTA HVMPSNSSAS VSKHRESLTP
DGSKWSTSLM QTLGDHSRGE RDSSLDMKDF RPLRKWSSLS KLTAPDTRNH SGIAYPQELR
NSLEMTGKGK PFMSHLRTFG PSCLHDSMEL LKLEDKEINK KRSSTLDCKY KFESCNKEDV
RVSSSALRRQ TLDMTYSALP ESKPIVTGSE TFESPKYLML GQQAVGGVPI QPSVRTQMWL
TEQLRTNPLE GRTTDDSYSL APWQQPQTEE FQQGSETPMQ VLTGSSRQSY SPPGFQDFSK
WESVLKIKEG LLRQKEIVID RQKQQINHLH ERIRDNELRA QHAMLGHYVN CEDSYVSNLQ
PQYESSSGQS LFTEQPLSHP HQEELEQKLA STEKEVLQLN EFLKQRISQF SEEKKKLEEK
LKTRDRYISS LKKKCQKESE QNKEKQRRIE TLEKYLADLP TLDDVQSQSL QLQVLEEKNK
NLQETLIDTE KQLEEIKKQC QDKEVQLLCQ KKKEKELVTS VQSLQQKVEK CLEDGIRLPM
LDAKQLQSEN DNLREQNATA SKIIESQQDE INRMILEIQS MQGKLCEEKL TARSTVEELG
RKEGSLQRLT EALLENQRQM GETYSLLDQG HEAEQSRPQT IHSKWPLFDL TVIDQLFKEM
SYCLFDLKAL CSILNQRAQG KEPNLSLLLG IRSMNCSAEE TENDHSPETL TKKLSDVCQL
RRDIDELRTT ISDRYAQDMG DNCVTQ
