CEA15_MOUSE
ID CEA15_MOUSE Reviewed; 234 AA.
AC A0A0B4J1L0; A0JLX4;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 1.
DT 03-AUG-2022, entry version 41.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 15 {ECO:0000312|Ensembl:ENSMUSP00000104138};
DE Flags: Precursor;
GN Name=Ceacam15 {ECO:0000312|MGI:MGI:2141810};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Ensembl:ENSMUSP00000104138, ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Ensembl:ENSMUSP00000104138,
RC ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:EDL42087.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAI25405.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=16139472; DOI=10.1016/j.ygeno.2005.07.008;
RA Zebhauser R., Kammerer R., Eisenried A., McLellan A., Moore T.,
RA Zimmermann W.;
RT "Identification of a novel group of evolutionarily conserved members within
RT the rapidly diverging murine Cea family.";
RL Genomics 86:566-580(2005).
RN [5] {ECO:0007744|PDB:4JGJ}
RP X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 26-140.
RA Kumar P.R., Bonanno J., Nathenson S.G., Almo S.C.;
RT "Crystal structure of the Ig-like D1 domain of CEACAM15 from Mus musculus
RT [NYSGRC-005691].";
RL Submitted (MAR-2013) to the PDB data bank.
CC -!- TISSUE SPECIFICITY: Detected in placenta.
CC {ECO:0000269|PubMed:16139472}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI25405.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI25407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC150681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466654; EDL42087.1; -; Genomic_DNA.
DR EMBL; BC125404; AAI25405.1; ALT_INIT; mRNA.
DR EMBL; BC125406; AAI25407.1; ALT_INIT; mRNA.
DR CCDS; CCDS52041.1; -.
DR RefSeq; NP_780524.1; NM_175315.1.
DR PDB; 4JGJ; X-ray; 2.65 A; A/B=31-145.
DR PDBsum; 4JGJ; -.
DR AlphaFoldDB; A0A0B4J1L0; -.
DR SMR; A0A0B4J1L0; -.
DR GlyGen; A0A0B4J1L0; 4 sites.
DR iPTMnet; A0A0B4J1L0; -.
DR PhosphoSitePlus; A0A0B4J1L0; -.
DR PaxDb; A0A0B4J1L0; -.
DR Ensembl; ENSMUST00000108498; ENSMUSP00000104138; ENSMUSG00000078795.
DR GeneID; 101434; -.
DR KEGG; mmu:101434; -.
DR UCSC; uc009fhy.2; mouse.
DR CTD; 101434; -.
DR MGI; MGI:2141810; Ceacam15.
DR VEuPathDB; HostDB:ENSMUSG00000078795; -.
DR eggNOG; ENOG502T1YP; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_4_1_1; -.
DR OMA; CITNEMD; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; A0A0B4J1L0; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 101434; 3 hits in 71 CRISPR screens.
DR PRO; PR:A0A0B4J1L0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; A0A0B4J1L0; protein.
DR Bgee; ENSMUSG00000078795; Expressed in ectoplacental cone and 14 other tissues.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..234
FT /note="Carcinoembryonic antigen-related cell adhesion
FT molecule 15"
FT /evidence="ECO:0000255"
FT /id="PRO_0000442297"
FT DOMAIN 146..226
FT /note="Ig-like C2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT STRAND 36..45
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 62..71
FT /evidence="ECO:0007829|PDB:4JGJ"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:4JGJ"
FT TURN 83..86
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 87..90
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 106..108
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 117..124
FT /evidence="ECO:0007829|PDB:4JGJ"
FT STRAND 130..140
FT /evidence="ECO:0007829|PDB:4JGJ"
SQ SEQUENCE 234 AA; 26408 MW; 8E387AEBC17ED631 CRC64;
MGAETMESPS LFLCKGLLLT ASLLICWNWS TAALLTSKEM RFSAAEGAKV LLSVPDQEEN
LLSFSWYKGK DVNENFTIAH YKKSSDSLQL GKKVSGREEI YKDGSMMLRA ITLEDTGFYT
LQTFKAHGQQ EVTHVHLQVY KIVTKPYLQL NHTRLKRKSA SILTCVSPDT GVDINWFFNY
KPLNATERIT LSPEKRELTI SPVWRADVGI YLCEVSNSFS SKKSYPLLMA LAYG
