ID   CEA16_RAT               Reviewed;         423 AA.
AC   D3ZQE1;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 16;
DE   Flags: Precursor;
GN   Name=Ceacam16;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: Required for proper hearing, plays a role in maintaining the
CC       integrity of the tectorial membrane. {ECO:0000250|UniProtKB:E9QA28,
CC       ECO:0000250|UniProtKB:Q2WEN9}.
CC   -!- SUBUNIT: Homooligomer; can for homodimers and homotetramers. Interacts
CC       with TECTA and TECTB. {ECO:0000250|UniProtKB:E9QA28,
CC       ECO:0000250|UniProtKB:Q2WEN9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:E9QA28}.
CC       Note=Localizes at the tip of cochlear outer hair cells and to the
CC       tectorial membrane. {ECO:0000250|UniProtKB:E9QA28}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
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DR   EMBL; AABR03001739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D3ZQE1; -.
DR   SMR; D3ZQE1; -.
DR   STRING; 10116.ENSRNOP00000041331; -.
DR   GlyGen; D3ZQE1; 2 sites.
DR   PaxDb; D3ZQE1; -.
DR   UCSC; RGD:1306386; rat.
DR   RGD; 1306386; Ceacam16.
DR   eggNOG; ENOG502S42Z; Eukaryota.
DR   InParanoid; D3ZQE1; -.
DR   PhylomeDB; D3ZQE1; -.
DR   TreeFam; TF336859; -.
DR   PRO; PR:D3ZQE1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF13895; Ig_2; 2.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..423
FT                   /note="Carcinoembryonic antigen-related cell adhesion
FT                   molecule 16"
FT                   /id="PRO_0000417875"
FT   DOMAIN          134..219
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          224..310
FT                   /note="Ig-like C2-type 2"
FT   REGION          77..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        155..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        253..294
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   423 AA;  45904 MW;  6CFE819F42433008 CRC64;
     MKMPLTWGSW FLLSAWILNA GAEISITPEP AQPAEGDNVT LVVHGLSGEL LAYNWYAGPS
     ISLTFLVASY IVSTGDETPG PAHTGREAVR PDGSLDIHGA LPGHTGTYIL QTLNRQFQTE
     VGYGHMQVYE ILAPPTVMAN DTALVERRDT LRLICSSPSP AEVRWFFNGD ALPVAVRLGL
     SPDGRMLTRH GVRREEAGAY QCEVWNPVSV SRSEPLNLTV YFGPERVAIL QDSTTRTGCT
     IKVDFNTSLT LWCVSRSCPE PEYVWAFNGK ALKNGQDHLN ISSMSADHEG TYTCIAKNSK
     TLLSGSASVV VKLSAAAVAM MIVPVPTKPM EGQDVTLTVQ GYPKDLLVYA WYRGPASEPN
     RLLSQLPSGN WIAGPAHTGR EVGFANCSLL VQKLNLTDAG RYTLKTVTLQ GKTDTLEVEL
     QVA