ID   CEA18_HUMAN             Reviewed;         384 AA.
AC   A8MTB9; C9JN24;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 4.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 18;
DE   Flags: Precursor;
GN   Name=CEACAM18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
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DR   EMBL; AC020914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MTB9; -.
DR   STRING; 9606.ENSP00000379738; -.
DR   GlyGen; A8MTB9; 5 sites.
DR   BioMuta; HGNC:31949; -.
DR   PaxDb; A8MTB9; -.
DR   PRIDE; A8MTB9; -.
DR   ProteomicsDB; 2012; -.
DR   Antibodypedia; 66739; 39 antibodies from 10 providers.
DR   Ensembl; ENST00000396477.4; ENSP00000379738.4; ENSG00000213822.6.
DR   UCSC; uc061bxs.1; human.
DR   GeneCards; CEACAM18; -.
DR   HGNC; HGNC:31949; CEACAM18.
DR   HPA; ENSG00000213822; Tissue enriched (intestine).
DR   neXtProt; NX_A8MTB9; -.
DR   OpenTargets; ENSG00000213822; -.
DR   PharmGKB; PA142672132; -.
DR   VEuPathDB; HostDB:ENSG00000213822; -.
DR   eggNOG; ENOG502RU0U; Eukaryota.
DR   GeneTree; ENSGT00960000186634; -.
DR   HOGENOM; CLU_024555_0_0_1; -.
DR   InParanoid; A8MTB9; -.
DR   OMA; SLAWEQM; -.
DR   TreeFam; TF336859; -.
DR   Pharos; A8MTB9; Tdark.
DR   PRO; PR:A8MTB9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A8MTB9; protein.
DR   Bgee; ENSG00000213822; Expressed in duodenum and 15 other tissues.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..384
FT                   /note="Carcinoembryonic antigen-related cell adhesion
FT                   molecule 18"
FT                   /id="PRO_0000339378"
FT   DOMAIN          227..314
FT                   /note="Ig-like C2-type"
FT   REGION          358..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        270
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        255..296
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         160
FT                   /note="L -> H (in dbSNP:rs8106673)"
FT                   /id="VAR_043976"
FT   VARIANT         161
FT                   /note="T -> A (in dbSNP:rs12610545)"
FT                   /id="VAR_043977"
SQ   SEQUENCE   384 AA;  43320 MW;  B7D3DDB65B282C3B CRC64;
     MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD KVPEDVQEYS
     WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL LIRPTALNDT GNYTVRVVAG
     NETQRATGWL EVLELGSNLG ISVNASSLVE NMDSVAADCL TNVTNITWYV NDVPTSSSDR
     MTISPDGKTL VILRVSRYDR TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN
     GIVTAEIGSQ VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN
     PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW SPDPCSDQPL
     LNQDKSGSMS VHPRPEDKTR RASR