CEA18_MOUSE
ID CEA18_MOUSE Reviewed; 376 AA.
AC Q9D871;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 18;
DE Flags: Precursor;
GN Name=Ceacam18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16139472; DOI=10.1016/j.ygeno.2005.07.008;
RA Zebhauser R., Kammerer R., Eisenried A., McLellan A., Moore T.,
RA Zimmermann W.;
RT "Identification of a novel group of evolutionarily conserved members within
RT the rapidly diverging murine Cea family.";
RL Genomics 86:566-580(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in the small and large intestine
CC and at lower levels also in other organs.
CC {ECO:0000269|PubMed:16139472}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; AK008389; BAB25642.1; -; mRNA.
DR EMBL; BC042780; AAH42780.1; -; mRNA.
DR CCDS; CCDS21177.1; -.
DR RefSeq; NP_082512.1; NM_028236.1.
DR AlphaFoldDB; Q9D871; -.
DR SMR; Q9D871; -.
DR STRING; 10090.ENSMUSP00000032663; -.
DR GlyGen; Q9D871; 3 sites.
DR PaxDb; Q9D871; -.
DR PRIDE; Q9D871; -.
DR ProteomicsDB; 281453; -.
DR Antibodypedia; 66739; 39 antibodies from 10 providers.
DR DNASU; 72431; -.
DR Ensembl; ENSMUST00000032663; ENSMUSP00000032663; ENSMUSG00000030472.
DR GeneID; 72431; -.
DR KEGG; mmu:72431; -.
DR UCSC; uc009gnf.1; mouse.
DR CTD; 729767; -.
DR MGI; MGI:1919681; Ceacam18.
DR VEuPathDB; HostDB:ENSMUSG00000030472; -.
DR eggNOG; ENOG502RU0U; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_024555_0_0_1; -.
DR InParanoid; Q9D871; -.
DR OMA; SLAWEQM; -.
DR OrthoDB; 888390at2759; -.
DR PhylomeDB; Q9D871; -.
DR TreeFam; TF336859; -.
DR BioGRID-ORCS; 72431; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9D871; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D871; protein.
DR Bgee; ENSMUSG00000030472; Expressed in small intestine Peyer's patch and 14 other tissues.
DR Genevisible; Q9D871; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..376
FT /note="Carcinoembryonic antigen-related cell adhesion
FT molecule 18"
FT /id="PRO_0000339379"
FT TOPO_DOM 31..330
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..376
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 229..314
FT /note="Ig-like C2-type"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 257..298
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 376 AA; 42215 MW; 9E095E8BA179DCF5 CRC64;
MDFSRPSFSP WRWLTLVASL LTCGICQASG QIFISPDSLL GVEKYRTILT LENVPEDVLE
YSWYRGKDNS TENMIFSYKP PNTRHPGPSY SGRENVTRAG SLVVRMSAVN DTGYYTVEVD
TSNETQRATG WLQIVKLRSN PGISANTSAL VEGMDSVVAK CLTNSSNISW YVNFVPTSGS
NRMTISPDGK TLIIHRVSRY DHTLQCAIED VPEILQKSEL IQLTVAYGPD YVSLWTQPYF
FAGVLTADIG SSVQLECNCF SKPEPRYHWI HNGSFLSIPE NNMTLPSLSW EQMGSYRCVV
ENPETQLTFY RDVTIQPPRP PLPTVNRELY IPGPLVIFLI LLTSLGGAFV CRVLVYSLFQ
SCSRGKTCHK CPWQTN
