CEA19_HUMAN
ID CEA19_HUMAN Reviewed; 300 AA.
AC Q7Z692; Q5XJ15; Q7Z693;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 19;
DE AltName: Full=Carcinoembryonic antigen-like 1;
DE Flags: Precursor;
GN Name=CEACAM19; Synonyms=CEAL1; ORFNames=UNQ2973/PRO7436;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY,
RP AND HORMONAL REGULATION.
RX PubMed=12801635; DOI=10.1016/s0378-1119(03)00499-2;
RA Scorilas A., Chiang P.M., Katsaros D., Yousef G.M., Diamandis E.P.;
RT "Molecular characterization of a new gene, CEAL1, encoding for a
RT carcinoembryonic antigen-like protein with a highly conserved domain of
RT eukaryotic translation initiation factors.";
RL Gene 310:79-89(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z692-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z692-2; Sequence=VSP_010708, VSP_010709;
CC Name=3;
CC IsoId=Q7Z692-3; Sequence=VSP_043228;
CC -!- TISSUE SPECIFICITY: Ubiquitous with highest expression in prostate,
CC uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle,
CC small intestine, and kidney, and lower expression in lung, cerebellum,
CC testis, liver, pancreas, bone marrow and ovary.
CC {ECO:0000269|PubMed:12801635}.
CC -!- INDUCTION: Down-regulated by dexamethasone (in vitro).
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP70002.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP70003.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF406955; AAP70002.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF406955; AAP70003.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY358394; AAQ88760.1; -; mRNA.
DR EMBL; AK291588; BAF84277.1; -; mRNA.
DR EMBL; AC092066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC083499; AAH83499.1; -; mRNA.
DR CCDS; CCDS12641.1; -. [Q7Z692-1]
DR CCDS; CCDS46108.1; -. [Q7Z692-3]
DR RefSeq; NP_001121365.1; NM_001127893.1. [Q7Z692-3]
DR RefSeq; NP_064604.2; NM_020219.3. [Q7Z692-1]
DR AlphaFoldDB; Q7Z692; -.
DR SMR; Q7Z692; -.
DR BioGRID; 121290; 1.
DR IntAct; Q7Z692; 1.
DR STRING; 9606.ENSP00000384887; -.
DR GlyGen; Q7Z692; 1 site.
DR iPTMnet; Q7Z692; -.
DR PhosphoSitePlus; Q7Z692; -.
DR BioMuta; CEACAM19; -.
DR DMDM; 55976788; -.
DR jPOST; Q7Z692; -.
DR PaxDb; Q7Z692; -.
DR PeptideAtlas; Q7Z692; -.
DR PRIDE; Q7Z692; -.
DR Antibodypedia; 53999; 136 antibodies from 22 providers.
DR DNASU; 56971; -.
DR Ensembl; ENST00000358777.10; ENSP00000351627.4; ENSG00000186567.14. [Q7Z692-3]
DR Ensembl; ENST00000403660.3; ENSP00000384887.3; ENSG00000186567.14. [Q7Z692-1]
DR GeneID; 56971; -.
DR KEGG; hsa:56971; -.
DR MANE-Select; ENST00000358777.10; ENSP00000351627.4; NM_001127893.3; NP_001121365.1. [Q7Z692-3]
DR UCSC; uc002ozo.5; human. [Q7Z692-1]
DR CTD; 56971; -.
DR DisGeNET; 56971; -.
DR GeneCards; CEACAM19; -.
DR HGNC; HGNC:31951; CEACAM19.
DR HPA; ENSG00000186567; Low tissue specificity.
DR MIM; 606691; gene.
DR neXtProt; NX_Q7Z692; -.
DR OpenTargets; ENSG00000186567; -.
DR PharmGKB; PA142672133; -.
DR VEuPathDB; HostDB:ENSG00000186567; -.
DR eggNOG; ENOG502SP3N; Eukaryota.
DR GeneTree; ENSGT00960000186634; -.
DR HOGENOM; CLU_081012_0_0_1; -.
DR InParanoid; Q7Z692; -.
DR OMA; GFANGSM; -.
DR OrthoDB; 1257953at2759; -.
DR PhylomeDB; Q7Z692; -.
DR TreeFam; TF352070; -.
DR PathwayCommons; Q7Z692; -.
DR SignaLink; Q7Z692; -.
DR BioGRID-ORCS; 56971; 11 hits in 1069 CRISPR screens.
DR GenomeRNAi; 56971; -.
DR Pharos; Q7Z692; Tbio.
DR PRO; PR:Q7Z692; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q7Z692; protein.
DR Bgee; ENSG00000186567; Expressed in apex of heart and 98 other tissues.
DR ExpressionAtlas; Q7Z692; baseline and differential.
DR Genevisible; Q7Z692; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..300
FT /note="Carcinoembryonic antigen-related cell adhesion
FT molecule 19"
FT /id="PRO_0000014576"
FT TOPO_DOM 33..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 259..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 142
FT /note="E -> D (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_010708"
FT VAR_SEQ 143..300
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_010709"
FT VAR_SEQ 282
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_043228"
SQ SEQUENCE 300 AA; 32638 MW; 677A8CD284514DC5 CRC64;
MEIPMGTQGC FSKSLLLSAS ILVLWMLQGS QAALYIQKIP EQPQKNQDLL LSVQGVPDTF
QDFNWYLGEE TYGGTRLFTY IPGIQRPQRD GSAMGQRDIV GFPNGSMLLR RAQPTDSGTY
QVAITINSEW TMKAKTEVQV AEKNKELPST HLPTNAGILA ATIIGSLAAG ALLISCIAYL
LVTRNWRGQS HRLPAPRGQG SLSILCSAVS PVPSVTPSTW MATTEKPELG PAHDAGDNNI
YEVMPSPVLL VSPISDTRSI NPARPLPTPP HLQAEPENHQ YQQDLLNPDP APYCQLVPTS
