CEAM3_RAT
ID CEAM3_RAT Reviewed; 709 AA.
AC Q63111; Q63101;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 3;
DE AltName: Full=Carcinoembryonic antigen CGM1;
DE Flags: Precursor;
GN Name=Ceacam3 {ECO:0000312|RGD:2333};
GN Synonyms=Cea1 {ECO:0000312|EMBL:AAA40908.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA66037.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAA66037.1};
RC TISSUE=Placenta {ECO:0000312|EMBL:AAA66037.1};
RX PubMed=2335509; DOI=10.1016/s0021-9258(19)39012-x;
RA Rebstock S., Lucas K., Thompson J.A., Zimmermann W.;
RT "cDNA and gene analyses imply a novel structure for a rat carcinoembryonic
RT antigen-related protein.";
RL J. Biol. Chem. 265:7872-7879(1990).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAA40908.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-141.
RC TISSUE=Liver {ECO:0000312|EMBL:AAA40908.1};
RX PubMed=2708349; DOI=10.1016/s0021-9258(18)83517-7;
RA Kodelja V., Lucas K., Barnert S., von Kleist S., Thompson J.A.,
RA Zimmermann W.;
RT "Identification of a carcinoembryonic antigen gene family in the rat:
RT Analysis of the N-terminal domains reveals immunoglobulin-like,
RT hypervariable regions.";
RL J. Biol. Chem. 264:6906-6912(1989).
CC -!- FUNCTION: Possibly involved in cell adhesion.
CC {ECO:0000303|PubMed:2335509}.
CC -!- TISSUE SPECIFICITY: Expression detected only in placenta.
CC {ECO:0000269|PubMed:2335509}.
CC -!- DEVELOPMENTAL STAGE: Expressed in both adult and embryo.
CC {ECO:0000269|PubMed:2335509}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000255}.
CC -!- CAUTION: This is not the ortholog of human CEACAM3. {ECO:0000305}.
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DR EMBL; M32474; AAA66037.1; -; mRNA.
DR EMBL; M60023; AAA40908.1; -; Genomic_DNA.
DR PIR; A33876; A33876.
DR PIR; A35364; A35364.
DR AlphaFoldDB; Q63111; -.
DR STRING; 10116.ENSRNOP00000023663; -.
DR GlyGen; Q63111; 16 sites.
DR PhosphoSitePlus; Q63111; -.
DR PaxDb; Q63111; -.
DR UCSC; RGD:2333; rat.
DR RGD; 2333; Ceacam3.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR InParanoid; Q63111; -.
DR PhylomeDB; Q63111; -.
DR Reactome; R-RNO-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR PRO; PR:Q63111; -.
DR Proteomes; UP000002494; Unplaced.
DR Gene3D; 2.60.40.10; -; 6.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF07686; V-set; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 6.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Immunoglobulin domain; Reference proteome; Repeat; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..709
FT /note="Carcinoembryonic antigen-related cell adhesion
FT molecule 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000014575"
FT DOMAIN 35..142
FT /note="Ig-like V-type 1"
FT /evidence="ECO:0000303|PubMed:2335509"
FT DOMAIN 155..262
FT /note="Ig-like V-type 2"
FT /evidence="ECO:0000303|PubMed:2335509"
FT DOMAIN 275..382
FT /note="Ig-like V-type 3"
FT /evidence="ECO:0000303|PubMed:2335509"
FT DOMAIN 393..500
FT /note="Ig-like V-type 4"
FT /evidence="ECO:0000303|PubMed:2335509"
FT DOMAIN 509..616
FT /note="Ig-like V-type 5"
FT /evidence="ECO:0000303|PubMed:2335509"
FT DOMAIN 631..695
FT /note="Ig-like C2-type"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 561
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 578
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 585
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 54
FT /note="H -> R (in Ref. 2; AAA40908)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 709 AA; 78311 MW; C9BC903D982D006A CRC64;
MELSSVLPCK RCTPWRGLLL TASLLTCWLL PTTAQVSIES LPPQVVEGEN VLLHVDNLPE
NLIAFVWYKG LTNMSLGVAL YSLTYNVTVT GPVHSGRETL YSNGSLWIQN VTQKDTGFYT
LRTISNHGEI VSNTSLHLHV YFSTLTCGRA ATSAQLSIES VPTSISKGES ALLLAHNLPE
NLRAIFWYKG AIVFKDLEVA RYVIGTNSSV PGPAHSGRET MYSNGSLLLQ NVTRNDAGFY
TLKTLSTDLK TEIAYVQLQV DTCFMSYAGP PTSAQLTVES APTSVAEGAS VLLLVHNLPE
NLRAIFWYKG VILFKDLEVA RYVIGTNSSV LGPAHSGRET MYSNGSLLLQ NVTRNDAGFY
TLRTLSTDLK AKVVHVQLQV NTSSCCDPLT PALLTIDPVP RHAAKGESVL LQVRNLPEDL
RMFIWFKSVY TSQIFKIAEY SRAINYVFRG PAHSGRETVY TNGSLLLQDA TEKDTGLYTL
QIIYRNFKIE TAHVQVSVHT CVHPSTTGQL VIESVPPNVV EGGDVLLLVH NMPENLQSFS
WYKGVAIVNR HEISRNIIAS NRSTLGPAHS GRETIYSNGS LLLHNATEED NGLYTLWTVN
RHSETQGIHV HIHIYKPVAQ PFIRVTESSV RVKSSVVLTC LSADTGTSIQ WLFNNQNLRL
TQRMSLSQTK CQLSIDPVRR EDAGEYRCEV SNPVSSKTSL PVSLDVIIE
