CEAMA_MOUSE
ID CEAMA_MOUSE Reviewed; 265 AA.
AC Q61400; Q99LD6; Q9D329;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 10;
DE Short=CEA-related cell adhesion molecule 10;
DE Short=CEA10;
DE Short=Carcinoembryonic antigen 10;
DE Flags: Precursor;
GN Name=Ceacam10; Synonyms=Cea10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Colon;
RX PubMed=7744068; DOI=10.1111/j.1432-1033.1995.0455k.x;
RA Keck U., Nedellec P., Beauchemin N., Thompson J., Zimmermann W.;
RT "The cea10 gene encodes a secreted member of the murine carcinoembryonic
RT antigen family and is expressed in the placenta, gastrointestinal tract and
RT bone marrow.";
RL Eur. J. Biochem. 229:455-464(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 34-53; 64-68; 99-104; 184-189 AND 235-249, FUNCTION,
RP GLYCOSYLATION AT ASN-44, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Seminal vesicle;
RX PubMed=15901639; DOI=10.1095/biolreprod.105.039651;
RA Li S.-H., Lee R.K.-K., Hsiao Y.-L., Chen Y.-H.;
RT "Demonstration of a glycoprotein derived from the Ceacam10 gene in mouse
RT seminal vesicle secretions.";
RL Biol. Reprod. 73:546-553(2005).
CC -!- FUNCTION: May interact with other CEACAM proteins on the sperm surface.
CC {ECO:0000269|PubMed:15901639}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000269|PubMed:15901639}.
CC -!- TISSUE SPECIFICITY: Abundant in seminal vesicle and traces in
CC epididymis and prostate (at protein level). Highly expressed in seminal
CC vesicle, minor in colon and placenta and, to a lesser extent, in small
CC intestine, caecum, stomach, salivary gland and bone marrow.
CC {ECO:0000269|PubMed:15901639}.
CC -!- DEVELOPMENTAL STAGE: Present in trace amounts on 5.5 dpc, increased
CC remarkably from 6.5 dpc to a maximum on 9.5 dpc and rapidly declined
CC thereafter to an almost undetectable level until delivery. First
CC appeared at a considerable level in 3-week-old mice. Thereafter, the
CC amount of transcript began increasing rapidly at 4-week-old mice and
CC reached a maximum in 7-week-old mice. {ECO:0000269|PubMed:15901639}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; L38422; AAB64011.1; -; mRNA.
DR EMBL; AK018529; BAB31256.1; -; mRNA.
DR EMBL; BC003346; AAH03346.1; -; mRNA.
DR CCDS; CCDS39833.1; -.
DR PIR; S69335; S69335.
DR RefSeq; NP_031701.3; NM_007675.4.
DR AlphaFoldDB; Q61400; -.
DR SMR; Q61400; -.
DR STRING; 10090.ENSMUSP00000037036; -.
DR GlyGen; Q61400; 3 sites.
DR iPTMnet; Q61400; -.
DR PaxDb; Q61400; -.
DR PRIDE; Q61400; -.
DR ProteomicsDB; 281458; -.
DR DNASU; 26366; -.
DR GeneID; 26366; -.
DR KEGG; mmu:26366; -.
DR UCSC; uc009fqm.2; mouse.
DR CTD; 26366; -.
DR MGI; MGI:1347248; Ceacam10.
DR eggNOG; ENOG502S42Z; Eukaryota.
DR InParanoid; Q61400; -.
DR OrthoDB; 998214at2759; -.
DR PhylomeDB; Q61400; -.
DR TreeFam; TF336859; -.
DR BioGRID-ORCS; 26366; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Ceacam10; mouse.
DR PRO; PR:Q61400; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q61400; protein.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; ISO:MGI.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000269|PubMed:15901639"
FT CHAIN 34..265
FT /note="Carcinoembryonic antigen-related cell adhesion
FT molecule 10"
FT /id="PRO_0000014574"
FT DOMAIN 35..142
FT /note="Ig-like V-type 1"
FT DOMAIN 155..262
FT /note="Ig-like V-type 2"
FT SITE 104
FT /note="Not glycosylated"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15901639"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 162
FT /note="P -> R (in Ref. 2; BAB31256)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="A -> T (in Ref. 3; AAH03346)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 29474 MW; FA22BBF66BE5C1B9 CRC64;
MELASAHLHK GQVPWVGLLL TASLLTYWSP ATTAQVTVEA VPPNVTADNN VLLLVHNLPQ
TLRVFYWYKG NSGAGHNEIG RFVTSINRSK MGLAHSGRET IYSNGSLFFQ SVTKNDEGVY
TLYMLDQNFE ITPISVRFHV HPSLLPSLSP PTTGQVTVEA VPPNVAEGEN VLLLVHNLPR
TLRAIYWYRG TTAGERNEIA RFITASNKII LGPAHSDREI IYNNGSLFFQ GVTKNDEGAY
ALDMLFQNFD HTLMPVQFNV HAKKQ
