CEC1_CAEEL
ID CEC1_CAEEL Reviewed; 304 AA.
AC P34618;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Chromo domain-containing protein cec-1;
GN Name=cec-1; ORFNames=ZK1236.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8812132; DOI=10.1006/dbio.1996.0221;
RA Agostoni E., Albertson D., Wittmann C., Hill F., Tobler H., Muller F.;
RT "cec-1, a soma-specific chromobox-containing gene in C. elegans.";
RL Dev. Biol. 178:316-326(1996).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8812132}. Chromosome
CC {ECO:0000269|PubMed:8812132}. Note=During mitosis it seems to
CC dissociate from the condensing chromosomes.
CC -!- DEVELOPMENTAL STAGE: Present in all somatic cells from the 50- to 80-
CC cell stage on throughout development and in adult animals.
CC {ECO:0000269|PubMed:8812132}.
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DR EMBL; FO080723; CCD66162.1; -; Genomic_DNA.
DR PIR; S44897; S44897.
DR RefSeq; NP_498862.1; NM_066461.4.
DR AlphaFoldDB; P34618; -.
DR SMR; P34618; -.
DR BioGRID; 41394; 4.
DR IntAct; P34618; 2.
DR STRING; 6239.ZK1236.2; -.
DR iPTMnet; P34618; -.
DR EPD; P34618; -.
DR PaxDb; P34618; -.
DR PeptideAtlas; P34618; -.
DR EnsemblMetazoa; ZK1236.2.1; ZK1236.2.1; WBGene00000414.
DR GeneID; 176190; -.
DR KEGG; cel:CELE_ZK1236.2; -.
DR UCSC; ZK1236.2; c. elegans.
DR CTD; 176190; -.
DR WormBase; ZK1236.2; CE00380; WBGene00000414; cec-1.
DR eggNOG; KOG2748; Eukaryota.
DR HOGENOM; CLU_915976_0_0_1; -.
DR InParanoid; P34618; -.
DR OMA; QYNGSHT; -.
DR OrthoDB; 1628171at2759; -.
DR Reactome; R-CEL-983231; Factors involved in megakaryocyte development and platelet production.
DR PRO; PR:P34618; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000414; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005721; C:pericentric heterochromatin; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..304
FT /note="Chromo domain-containing protein cec-1"
FT /id="PRO_0000080240"
FT DOMAIN 8..66
FT /note="Chromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT REGION 63..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..209
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 304 AA; 33784 MW; 036C591CCE629D2E CRC64;
MADGSELYTV ESILEHRKKK GKSEFYIKWL GYDHTHNSWE PKENIVDPTL IEAFFTREAA
RKAEIKAKKD KMAAGKKGAS SKASASVSKA SASTPARGAK AAPKPPPKKS PPKRQRLAGG
DIRPDSDTDE EHSSADKKSK AEDEEEVEDD EEPVPKKKKE VQEEPEEEES VEGEDEEESQ
EVEDLKEDEK MEEDEKEEEE DVQLESEKNE KEEEEEKVEE KKEEEEEEEE EEIQLVIVEK
TVIETTIVEP AVATPEPSEP SSSEKAVVEN GSSSAAAGNS ASKPEVSAVE VVTVEDDDDI
AIIE
