ID   CEC1_DROVI              Reviewed;          63 AA.
AC   Q94557; B4M6E1; Q94558;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cecropin-1/3;
DE   Flags: Precursor;
GN   Name=Cec1; ORFNames=GJ10758;
GN   and
GN   Name=Cec3; ORFNames=GJ10755;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CEC1 AND CEC3).
RX   PubMed=9060393; DOI=10.1007/pl00006144;
RA   Zhou X., Nguyen T., Kimbrell D.A.;
RT   "Identification and characterization of the Cecropin antibacterial protein
RT   gene locus in Drosophila virilis.";
RL   J. Mol. Evol. 44:272-281(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CEC1 AND CEC3).
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; U71249; AAB18322.1; -; Genomic_DNA.
DR   EMBL; U71249; AAB18324.1; -; Genomic_DNA.
DR   EMBL; CH940652; EDW59217.1; -; Genomic_DNA.
DR   EMBL; CH940652; EDW59219.1; -; Genomic_DNA.
DR   RefSeq; XP_002056105.1; XM_002056069.2.
DR   RefSeq; XP_002056107.2; XM_002056071.2.
DR   AlphaFoldDB; Q94557; -.
DR   SMR; Q94557; -.
DR   STRING; 7244.FBpp0225172; -.
DR   EnsemblMetazoa; FBtr0226680; FBpp0225172; FBgn0017815.
DR   GeneID; 6632628; -.
DR   GeneID; 6632630; -.
DR   KEGG; dvi:6632628; -.
DR   KEGG; dvi:6632630; -.
DR   eggNOG; ENOG502TCNK; Eukaryota.
DR   HOGENOM; CLU_187909_1_0_1; -.
DR   InParanoid; Q94557; -.
DR   OMA; NRIFVFV; -.
DR   OrthoDB; 1632391at2759; -.
DR   PhylomeDB; Q94557; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..62
FT                   /note="Cecropin-1/3"
FT                   /id="PRO_0000004856"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        48
FT                   /note="L -> V (in Ref. 1; AAB18324)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   63 AA;  6785 MW;  35A35208B51D6A84 CRC64;
     MNFYKVFIFV ALILAISLGQ SEAGWLKKIG KKIERIGQHT RDATIQGLGI AQQAANVAAT
     ARG