ID   CEC2_CERCA              Reviewed;          63 AA.
AC   Q06590;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cecropin-2;
DE   Flags: Precursor;
GN   Name=CEC2;
OS   Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC   Tephritidae; Ceratitis; Ceratitis.
OX   NCBI_TaxID=7213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7916722; DOI=10.1016/0378-1119(93)90100-h;
RA   Rosetto M., Manetti A.G.O., Marchini D., Dallai R., Telford J.L.,
RA   Baldari C.T.;
RT   "Sequences of two cDNA clones from the medfly Ceratitis capitata encoding
RT   antibacterial peptides of the cecropin family.";
RL   Gene 134:241-243(1993).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; X70029; CAA49617.1; -; mRNA.
DR   PIR; JT0674; JT0674.
DR   RefSeq; XP_004534330.1; XM_004534273.2.
DR   RefSeq; XP_012160526.1; XM_012305136.1.
DR   AlphaFoldDB; Q06590; -.
DR   SMR; Q06590; -.
DR   GeneID; 101456416; -.
DR   KEGG; ccat:101456416; -.
DR   OrthoDB; 1632391at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..23
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004834"
FT   CHAIN           24..62
FT                   /note="Cecropin-2"
FT                   /id="PRO_0000004835"
FT   MOD_RES         62
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6736 MW;  F68E41FEEF25F6E0 CRC64;
     MNFNKVLVLL AVIFAVFAGQ TEAGWLKKIG KKIERVGQHT RDATIQTIGV AQQAANVAAT
     LKG