ID   CEC2_DROVI              Reviewed;          63 AA.
AC   Q94990; B4M6E0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cecropin-2;
DE   Flags: Precursor;
GN   Name=Cec2A; ORFNames=GJ10757;
GN   and
GN   Name=Cec2B; ORFNames=GJ10406;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CEC2A AND CEC2B).
RX   PubMed=9060393; DOI=10.1007/pl00006144;
RA   Zhou X., Nguyen T., Kimbrell D.A.;
RT   "Identification and characterization of the Cecropin antibacterial protein
RT   gene locus in Drosophila virilis.";
RL   J. Mol. Evol. 44:272-281(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CEC2A AND CEC2B).
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; U71249; AAB18323.1; -; Genomic_DNA.
DR   EMBL; U71249; AAB18325.1; -; Genomic_DNA.
DR   EMBL; CH940652; EDW59216.1; -; Genomic_DNA.
DR   EMBL; CH940652; EDW59218.1; -; Genomic_DNA.
DR   RefSeq; XP_002056104.1; XM_002056068.2.
DR   RefSeq; XP_002056106.2; XM_002056070.2.
DR   AlphaFoldDB; Q94990; -.
DR   SMR; Q94990; -.
DR   STRING; 7244.FBpp0224823; -.
DR   EnsemblMetazoa; FBtr0226331; FBpp0224823; FBgn0017816.
DR   GeneID; 6632627; -.
DR   GeneID; 6632629; -.
DR   KEGG; dvi:6632627; -.
DR   KEGG; dvi:6632629; -.
DR   eggNOG; ENOG502TCNK; Eukaryota.
DR   HOGENOM; CLU_187909_1_0_1; -.
DR   InParanoid; Q94990; -.
DR   OMA; EPIAICN; -.
DR   OrthoDB; 1632391at2759; -.
DR   PhylomeDB; Q94990; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..62
FT                   /note="Cecropin-2"
FT                   /id="PRO_0000004857"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6771 MW;  35A3521644F26A84 CRC64;
     MNFYKVFIFV ALILAISLGQ SEAGWLKKIG KKIERVGQHT RDATIQGLGI AQQAANVAAT
     ARG