ID   CEC4_MANSE              Reviewed;          37 AA.
AC   P14664;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Bactericidin B-4;
DE   AltName: Full=Cecropin-like peptide B-4;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT GLY-37.
RX   PubMed=3143727; DOI=10.1016/s0021-9258(19)77650-9;
RA   Dickinson L., Russel V., Dunn P.E.;
RT   "A family of bacteria-regulated, cecropin D-like peptides from Manduca
RT   sexta.";
RL   J. Biol. Chem. 263:19424-19429(1988).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   PIR; C32021; C32021.
DR   AlphaFoldDB; P14664; -.
DR   SMR; P14664; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Bactericidin B-4"
FT                   /id="PRO_0000044684"
FT   MOD_RES         37
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000305|PubMed:3143727"
SQ   SEQUENCE   37 AA;  3862 MW;  5D74827782B03874 CRC64;
     WNPFKELERA GQRVRDAIIS AAPAVATVGQ AAAIARG