ID   CEC5_MANSE              Reviewed;          61 AA.
AC   P14665;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Bactericidin B-5P;
DE   AltName: Full=Cecropin-like peptide B-5;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT GLY-60.
RX   PubMed=3143727; DOI=10.1016/s0021-9258(19)77650-9;
RA   Dickinson L., Russel V., Dunn P.E.;
RT   "A family of bacteria-regulated, cecropin D-like peptides from Manduca
RT   sexta.";
RL   J. Biol. Chem. 263:19424-19429(1988).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; M23661; AAA29306.1; -; mRNA.
DR   EMBL; M23662; AAA29307.1; -; mRNA.
DR   PIR; D32021; D32021.
DR   AlphaFoldDB; P14665; -.
DR   SMR; P14665; -.
DR   TCDB; 1.C.17.1.4; the cecropin (cecropin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000305"
FT   PROPEP          23..24
FT                   /note="Removed by a dipeptidylpeptidase"
FT                   /id="PRO_0000004873"
FT   CHAIN           25..60
FT                   /note="Bactericidin B-5P"
FT                   /id="PRO_0000004874"
FT   MOD_RES         60
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000305|PubMed:3143727"
SQ   SEQUENCE   61 AA;  6389 MW;  B601CA3E90FDB40C CRC64;
     MNFSRVLFFV FACLSAFAMA SAAPWNPFKE LERAGQRVRD AVISAAAVAT VGQAAAIARG
     G