ID   CECA1_AEDAL             Reviewed;          59 AA.
AC   P81417; Q963B1;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Cecropin-A1;
DE   AltName: Full=AalCecA;
DE   AltName: Full=Cecropin-A;
DE   Flags: Precursor;
GN   Name=CECA1; Synonyms=CECA;
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10413113; DOI=10.1016/s0014-5793(99)00799-1;
RA   Sun D., Eccleston E.D., Fallon A.M.;
RT   "Cloning and expression of three cecropin cDNAs from a mosquito cell
RT   line.";
RL   FEBS Lett. 454:147-151(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sun D., Fallon A.M.;
RT   "Characterization of genomic DNA encoding mosquito cecropins.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 24-58.
RX   PubMed=9712710; DOI=10.1006/bbrc.1998.9150;
RA   Sun D., Eccleston E.D., Fallon A.M.;
RT   "Peptide sequence of an antibiotic cecropin from the vector mosquito, Aedes
RT   albopictus.";
RL   Biochem. Biophys. Res. Commun. 249:410-415(1998).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AF145802; AAD37701.1; -; mRNA.
DR   EMBL; AF394744; AAK81849.1; -; Genomic_DNA.
DR   AlphaFoldDB; P81417; -.
DR   SMR; P81417; -.
DR   Proteomes; UP000069940; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:9712710"
FT   CHAIN           24..58
FT                   /note="Cecropin-A1"
FT                   /id="PRO_0000004812"
SQ   SEQUENCE   59 AA;  6136 MW;  84BC07E43D8AECC2 CRC64;
     MNFTKLFAIV LLAALVLLGQ TEAGGLKKLG KKLEGVGKRV FKASEKALPV AVGIKALGK