ID   CECA1_DROMA             Reviewed;          63 AA.
AC   P81685;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Cecropin-A1;
DE   Flags: Precursor;
GN   Name=CecA1;
OS   Drosophila mauritiana (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M31;
RX   PubMed=9335607; DOI=10.1093/genetics/147.2.713;
RA   Clark A.G., Wang L.;
RT   "Molecular population genetics of Drosophila immune system genes.";
RL   Genetics 147:713-724(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Montemayor;
RX   PubMed=9725836; DOI=10.1093/genetics/150.1.157;
RA   Ramos-Onsins S., Aguade M.;
RT   "Molecular evolution of the Cecropin multigene family in Drosophila:
RT   functional genes vs pseudogenes.";
RL   Genetics 150:157-171(1998).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AF018975; AAB82472.1; -; Genomic_DNA.
DR   EMBL; Y16863; CAA76488.1; -; Genomic_DNA.
DR   AlphaFoldDB; P81685; -.
DR   FlyBase; FBgn0023320; Dmau\CecA1.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..62
FT                   /note="Cecropin-A1"
FT                   /id="PRO_0000004840"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   VARIANT         2
FT                   /note="K -> N (in strain: M31)"
FT   VARIANT         50
FT                   /note="V -> I (in strain: M31)"
SQ   SEQUENCE   63 AA;  6771 MW;  F07E770C5BF1DB74 CRC64;
     MKFYNIFVFV ALILAITIGQ SEAGWLKKIG KKIERVGQHT RDATIQGLGV AQQAANVAAT
     ARG