ID   CECA2_AEDAL             Reviewed;          59 AA.
AC   Q963B0;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Cecropin-A2;
DE   Flags: Precursor;
GN   Name=CECA2;
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sun D., Fallon A.M.;
RT   "Characterization of genomic DNA encoding mosquito cecropins.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AF394745; AAK81850.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q963B0; -.
DR   SMR; Q963B0; -.
DR   EnsemblMetazoa; AALF000656-RA; AALF000656-PA; AALF000656.
DR   VEuPathDB; VectorBase:AALF000656; -.
DR   Proteomes; UP000069940; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..58
FT                   /note="Cecropin-A2"
FT                   /id="PRO_0000004813"
SQ   SEQUENCE   59 AA;  6183 MW;  CE5C1DFE3D8AE673 CRC64;
     MNFNKLFAIV LLAALVLLGQ TEAGGLKKFG KKLEGVGKRV FKASEKALPV AVGIKALGK