ID   CECA2_DROYA             Reviewed;          56 AA.
AC   O61281;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Cecropin-A2;
DE   Flags: Fragment;
GN   Name=CecA2;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9553148; DOI=10.1007/s002510050379;
RA   Date A., Satta Y., Takahata N., Chigusa S.I.;
RT   "Evolutionary history and mechanism of the Drosophila cecropin gene
RT   family.";
RL   Immunogenetics 47:417-429(1998).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AB010798; BAA28744.1; -; Genomic_DNA.
DR   AlphaFoldDB; O61281; -.
DR   EnsemblMetazoa; FBtr0257384; FBpp0255876; FBgn0228701.
DR   FlyBase; FBgn0025013; Dyak\CecA2.
DR   OrthoDB; 1632391at2759; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted.
FT   CHAIN           <1..55
FT                   /note="Cecropin-A2"
FT                   /id="PRO_0000127103"
FT   MOD_RES         55
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   56 AA;  5811 MW;  BC9E06AD4BE37826 CRC64;
     VFVALILAIA IGQSEAGWLK KIGKKIERVG QHTRDATIQG LGIAQQAANV AATARG