ID   CECA_BOMMO              Reviewed;          63 AA.
AC   Q27239;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Cecropin-A;
DE   Flags: Precursor;
GN   Name=CECA;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C108; TISSUE=Larval fat body;
RX   PubMed=7765280; DOI=10.1271/bbb.58.1476;
RA   Yamano Y., Matsumoto M., Inoue K., Kawabata T., Morishima I.;
RT   "Cloning of cDNAs for cecropins A and B, and expression of the genes in the
RT   silkworm, Bombyx mori.";
RL   Biosci. Biotechnol. Biochem. 58:1476-1478(1994).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highest expression in fat body and hemocytes. Is
CC       also expressed in Malpighian tubules and to a much lesser extent in
CC       midgut. Not present in silk gland.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; D17394; BAA04217.1; -; mRNA.
DR   EMBL; S74376; AAC60515.1; -; mRNA.
DR   PIR; JC2295; CKMTA.
DR   RefSeq; NP_001037030.1; NM_001043565.1.
DR   RefSeq; NP_001037462.1; NM_001043997.1.
DR   RefSeq; XP_004933962.1; XM_004933905.2.
DR   AlphaFoldDB; Q27239; -.
DR   SMR; Q27239; -.
DR   STRING; 7091.BGIBMGA006280-TA; -.
DR   EnsemblMetazoa; BGIBMGA006280-RA; BGIBMGA006280-TA; BGIBMGA006280.
DR   EnsemblMetazoa; BGIBMGA014285-RA; BGIBMGA014285-TA; BGIBMGA014285.
DR   GeneID; 101743336; -.
DR   GeneID; 693029; -.
DR   KEGG; bmor:101743336; -.
DR   KEGG; bmor:693029; -.
DR   CTD; 693029; -.
DR   eggNOG; ENOG502T7RS; Eukaryota.
DR   HOGENOM; CLU_187909_0_0_1; -.
DR   InParanoid; Q27239; -.
DR   OMA; PRWKLFK; -.
DR   OrthoDB; 1635266at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..26
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004824"
FT   CHAIN           27..61
FT                   /note="Cecropin-A"
FT                   /evidence="ECO:0000269|PubMed:7765280"
FT                   /id="PRO_0000004825"
FT   MOD_RES         61
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6762 MW;  6A1C39975516D86A CRC64;
     MNFVRILSFV FALVLALGAV SAAPEPRWKL FKKIEKVGRN VRDGLIKAGP AIAVIGQAKS
     LGK