ID   CECA_CULPP              Reviewed;          59 AA.
AC   Q86PR6;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Cecropin-A;
DE   Flags: Precursor;
GN   Name=CECA;
OS   Culex pipiens pipiens (Northern house mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=38569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Iowa state;
RA   Bartholomay L.C., Farid H.A., Ramzy R.M., Christensen B.M.;
RT   "Innate immunity in the Culex pipiens-Wuchereria bancrofti host-parasite
RT   relationship.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AY189808; AAO38516.1; -; mRNA.
DR   AlphaFoldDB; Q86PR6; -.
DR   SMR; Q86PR6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..57
FT                   /note="Cecropin-A"
FT                   /id="PRO_0000004836"
FT   MOD_RES         57
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   59 AA;  6285 MW;  26CE3D7E823D9296 CRC64;
     MNFNKLFVIV LLAALAFFGQ AEAGGLKKFG KKLEGVGKRV FKASEKALPV VTGFKALGK