ID   CECA_SPOLT              Reviewed;          57 AA.
AC   Q9XZG9;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Cecropin-A;
DE   Flags: Precursor; Fragment;
GN   Name=CECA;
OS   Spodoptera litura (Asian cotton leafworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Amphipyrinae; Spodoptera.
OX   NCBI_TaxID=69820;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION,
RP   SUBCELLULAR LOCATION, AND INDUCTION.
RC   TISSUE=Larval hemolymph;
RX   PubMed=11790350; DOI=10.1016/s0742-8413(99)00117-6;
RA   Choi C.S., Lee I.H., Kim E., Kim S.I., Kim H.R.;
RT   "Antibacterial properties and partial cDNA sequences of cecropin-like
RT   antibacterial peptides from the common cutworm, Spodoptera litura.";
RL   Comp. Biochem. Physiol. 125C:287-297(2000).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC       {ECO:0000269|PubMed:11790350}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11790350}.
CC   -!- INDUCTION: Induced as part of the humoral response to a bacterial
CC       invasion. Transcripts appear within the immunized fat body.
CC       {ECO:0000269|PubMed:11790350}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AF142341; AAD29438.1; -; mRNA.
DR   AlphaFoldDB; Q9XZG9; -.
DR   SMR; Q9XZG9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          <1..21
FT                   /evidence="ECO:0000269|PubMed:11790350"
FT   CHAIN           22..57
FT                   /note="Cecropin-A"
FT                   /id="PRO_0000004878"
FT   NON_TER         1
SQ   SEQUENCE   57 AA;  6070 MW;  60ABBAD85A5E68B9 CRC64;
     IFFFVFACLL ALSAVSAAPE PRWKVFKKIE KVGRNVRDGI IKAGPAIGVL GQAKALG