ID   CECB1_AEDAL             Reviewed;          60 AA.
AC   Q9Y0Y0;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Cecropin-B type 1;
DE            Short=Cecropin-B1;
DE   Contains:
DE     RecName: Full=Cecropin-B;
DE     AltName: Full=AalCecB;
DE   Contains:
DE     RecName: Full=Cecropin-B amidated isoform;
DE   Flags: Precursor;
GN   Name=CECB1; Synonyms=CECB;
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-59, DEVELOPMENTAL STAGE,
RP   MASS SPECTROMETRY, AND AMIDATION AT ILE-58.
RX   PubMed=10413113; DOI=10.1016/s0014-5793(99)00799-1;
RA   Sun D., Eccleston E.D., Fallon A.M.;
RT   "Cloning and expression of three cecropin cDNAs from a mosquito cell
RT   line.";
RL   FEBS Lett. 454:147-151(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sun D., Fallon A.M.;
RT   "Characterization of genomic DNA encoding mosquito cecropins.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Expressed within 2 hours after induction and
CC       continued to accumulate over 24 hours. {ECO:0000269|PubMed:10413113}.
CC   -!- INDUCTION: By bacterial infection.
CC   -!- MASS SPECTROMETRY: [Cecropin-B]: Mass=3642.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10413113};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; AF145803; AAD37702.1; -; mRNA.
DR   EMBL; AF394747; AAK81853.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9Y0Y0; -.
DR   SMR; Q9Y0Y0; -.
DR   Proteomes; UP000069940; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:10413113"
FT   CHAIN           25..59
FT                   /note="Cecropin-B"
FT                   /id="PRO_0000004814"
FT   CHAIN           25..58
FT                   /note="Cecropin-B amidated isoform"
FT                   /id="PRO_0000004815"
FT   MOD_RES         58
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|PubMed:10413113"
SQ   SEQUENCE   60 AA;  6372 MW;  0229B1C156AACADB CRC64;
     MNFNKLFALV LLIGLVLLTG QTEAGGLKKL GKKLEGVGKR VFKASEKALP VLTGYKAIGK