ID   CECB_ANOGA              Reviewed;          60 AA.
AC   Q8MUF4; Q7QEE2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Cecropin-B;
DE   Flags: Precursor;
GN   Name=CecB; Synonyms=CEC3; ORFNames=AGAP000694;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12421409; DOI=10.1046/j.1365-2583.2002.00360.x;
RA   Zheng X.-L., Zheng A.L.;
RT   "Genomic organization and regulation of three cecropin genes in Anopheles
RT   gambiae.";
RL   Insect Mol. Biol. 11:517-525(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF525673; AAM82611.1; -; Genomic_DNA.
DR   EMBL; AAAB01008847; EAA06859.2; -; Genomic_DNA.
DR   RefSeq; XP_311224.2; XM_311224.3.
DR   AlphaFoldDB; Q8MUF4; -.
DR   SMR; Q8MUF4; -.
DR   STRING; 7165.AGAP000694-PA; -.
DR   PaxDb; Q8MUF4; -.
DR   GeneID; 1272282; -.
DR   KEGG; aga:AgaP_AGAP000694; -.
DR   CTD; 1272282; -.
DR   VEuPathDB; VectorBase:AGAP000694; -.
DR   eggNOG; ENOG502T99E; Eukaryota.
DR   HOGENOM; CLU_187909_1_1_1; -.
DR   InParanoid; Q8MUF4; -.
DR   OMA; APRWKFG; -.
DR   OrthoDB; 1627823at2759; -.
DR   PhylomeDB; Q8MUF4; -.
DR   Proteomes; UP000007062; Chromosome X.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..59
FT                   /note="Cecropin-B"
FT                   /id="PRO_0000004822"
FT   MOD_RES         59
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   60 AA;  6537 MW;  8CAAE0CFE3ABAC83 CRC64;
     MNFTKLFILV AIAVLVVVGV QPVDGAPRWK FGKRLEKLGR NVFRAAKKAL PVIAGYKALG