ID   CECB_DROSI              Reviewed;          63 AA.
AC   P67792; B4R1K3; O61273; P81689;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cecropin-B;
DE   Flags: Precursor;
GN   Name=CecB; ORFNames=GD17190;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Montemayor;
RX   PubMed=9725836; DOI=10.1093/genetics/150.1.157;
RA   Ramos-Onsins S., Aguade M.;
RT   "Molecular evolution of the Cecropin multigene family in Drosophila:
RT   functional genes vs pseudogenes.";
RL   Genetics 150:157-171(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9553148; DOI=10.1007/s002510050379;
RA   Date A., Satta Y., Takahata N., Chigusa S.I.;
RT   "Evolutionary history and mechanism of the Drosophila cecropin gene
RT   family.";
RL   Immunogenetics 47:417-429(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   EMBL; Y16860; CAA76475.1; -; Genomic_DNA.
DR   EMBL; AB010790; BAA28718.1; -; Genomic_DNA.
DR   EMBL; CM000364; EDX14991.1; -; Genomic_DNA.
DR   RefSeq; XP_002105488.1; XM_002105452.2.
DR   AlphaFoldDB; P67792; -.
DR   STRING; 7240.P67792; -.
DR   EnsemblMetazoa; FBtr0217100; FBpp0215592; FBgn0025038.
DR   GeneID; 6730203; -.
DR   HOGENOM; CLU_187909_1_0_1; -.
DR   OMA; GHSEANW; -.
DR   PhylomeDB; P67792; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0025038; Expressed in adult organism.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:EnsemblMetazoa.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0002213; P:defense response to insect; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   InterPro; IPR020400; Cecropin_insect.
DR   PANTHER; PTHR38329; PTHR38329; 1.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..62
FT                   /note="Cecropin-B"
FT                   /id="PRO_0000004846"
FT   MOD_RES         62
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6792 MW;  26D023AD28A98AB4 CRC64;
     MNFNKIFVFV ALILAISLGN TEAGWLRKLG KKIERIGQHT RDASIQVLGI AQQAANVAAT
     ARG