ID   CECB_HELVI              Reviewed;          33 AA.
AC   P83414;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Cecropin-B;
DE   Flags: Fragment;
OS   Heliothis virescens (Tobacco budworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Heliothis.
OX   NCBI_TaxID=7102 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, INDUCTION, MASS SPECTROMETRY, AND HYDROXYLATION AT LYS-21.
RC   TISSUE=Hemolymph;
RA   Bulet P., Lamberty M., Brookhart G., Bushey D.;
RL   Submitted (JUL-2002) to UniProtKB.
CC   -!- FUNCTION: Cecropins have lytic and antibacterial activity against
CC       several Gram-positive and Gram-negative bacteria. Has also activity
CC       against fungi. {ECO:0000269|Ref.1}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3847.87; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the cecropin family. {ECO:0000305}.
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DR   AlphaFoldDB; P83414; -.
DR   SMR; P83414; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:InterPro.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
DR   PROSITE; PS00268; CECROPIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Hydroxylation; Immunity; Innate immunity; Secreted.
FT   CHAIN           1..>33
FT                   /note="Cecropin-B"
FT                   /id="PRO_0000127104"
FT   MOD_RES         21
FT                   /note="5-hydroxylysine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   NON_TER         33
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   33 AA;  3605 MW;  32176D21631546E0 CRC64;
     KWKVFKKIEK VGRNIRDGIV KAGPAIAVLG QAN